Meta-analysis finds distinct neural activation patterns to food and monetary rewards in overweight/obesity
Brain scans reveal how food and money rewards differ in people with overweight or obesity
A meta-analysis of 26 fMRI studies (1065 participants) found individuals with overweight/obesity show both overlapping and distinct neural a…
Researchers analyzed brain scan data from over 1,000 people to see how brains respond to food and money rewards.
Cognitive training add-on to behavioral weight-loss intervention shows moderate BMI reductions at 6 months
Cognitive training added to weight loss program shows modest benefits in small trial
A randomized trial in 148 adults with excess weight found that adding comprehensive cognitive training to standard behavioral weight-loss in…
Adding mental exercises to a weight loss program helped adults lose more weight and lower their BMI compared to standard care alone.
Calorie restriction plus exercise reduced IL-6 and knee pain more than diet alone in knee OA
Small study finds adding exercise to calorie restriction may reduce knee pain and inflammation
A 4-week RCT in 23 overweight/obese adults with knee osteoarthritis compared calorie restriction alone to restriction plus aerobic exercise.
Adding exercise to a calorie-reduced diet lowered knee pain and a specific inflammation marker in overweight people with knee osteoarthritis…
GLP-1RAs reduce MACE risk in Asian and White adults with diabetes or overweight
Do heart benefits from diabetes drugs work equally well across different races?
A meta-analysis of 74,703 adults with type 2 diabetes or overweight/obesity found GLP-1RAs reduced MACE risk versus placebo.
Diabetes drugs protect hearts in Asian and White adults, but the benefit for Black adults remains unclear due to small study numbers.
Liraglutide reduces OSA severity in patients with COPD and obesity in exploratory analysis
Could a weight loss drug help people with COPD breathe easier at night?
A secondary exploratory analysis of a 40-week RCT in 40 patients with COPD and overweight/obesity found liraglutide (3.0 mg) significantly r…
A weight loss drug reduced breathing pauses and oxygen drops for people with COPD and sleep apnea, improving general health while day-time s…
Phase II RCT: Amiloride reduces arterial stiffness and blood pressure in adults with obesity and metabolic syndrome
Low-dose amiloride reduced arterial stiffness and blood pressure in adults with obesity
A phase II, single-center RCT of 137 adults with overweight/obesity and metabolic syndrome features found 24 weeks of low-dose amiloride (5 …
Low-dose amiloride reduced arterial stiffness and blood pressure in adults with obesity, offering a potential new tool to improve heart heal…
HIIT plus Spirulina supplementation alters inflammatory biomarkers in young men with obesity
Can exercise and algae supplements change inflammation in men with obesity?
A 12-week RCT in 64 young men with obesity found that combining HIIT with Spirulina supplementation increased IL-10 and ApoM while decreasin…
Combining high-intensity exercise with a daily blue-green algae supplement produced the strongest drop in inflammation markers among young m…
Phase 1b trial of oral GLP-1 agonist HDM1002 shows weight reduction in Chinese adults with overweight/obesity
Can a new pill help with weight loss? Early trial shows promise
A phase 1b randomized controlled trial in Chinese adults with overweight/obesity without diabetes found greater weight reductions with oral …
A new oral weight-loss pill helped adults lose about 6 kilograms in just 28 days, showing early promise compared to a placebo.
Primary care clinicians report readiness for GLP-1 obesity care but note gaps in behavioral intervention competence
Do your doctors feel ready to help you with obesity now that new treatments are available?
This early-phase survey assessed the competence, attitudes, and confidence of 276 primary care clinicians regarding obesity management.
Doctors feel ready to treat obesity with new drugs, yet admit their skills in lifestyle advice and ongoing support still fall short of what …
GLP-1 receptor agonists associated with lower respiratory sequelae risk in case report analysis
Could diabetes drugs help protect lungs? A new analysis of patient stories suggests a link
An analysis of 136 single-patient case reports from PubMed Open Access found that GLP-1 receptor agonist users had a lower risk of respirato…
Diabetes drugs linked to lower risk of serious lung problems in a new look at patient stories.
Plant bioactive polysaccharides show metabolic benefits in umbrella review of systematic reviews
Plant polysaccharides show potential benefits for blood sugar, cholesterol, and gut health
An umbrella review of systematic reviews and meta-analyses found plant bioactive polysaccharides had significant effects on blood lipids and…
Plant polysaccharides linked to better blood sugar, cholesterol, gut health, and weight control, though no effect on blood pressure or liver…
Prediabetes in youth with overweight/obesity associated with lower baseline cognition, stable over 2 years
Could prediabetes affect how young people with obesity think and learn?
A 2-year longitudinal observational study of 67 youth with overweight/obesity found those with prediabetes had lower IQ and poorer executive…
Youth with prediabetes show lower IQ and slower thinking skills compared to peers with normal blood sugar, and these cognitive differences s…