Solid organ transplant recipients face higher cancer-related mortality with SMR 2.21 across multiple organs
Organ transplant recipients face higher risk of certain cancers
This meta-analysis of multi-centre cohort and registry-based studies indicates that solid organ transplant recipients experience significant…
People who receive heart or lung transplants face a significantly higher risk of dying from specific types of cancer.
Panax ginseng flower phytochemicals demonstrate antioxidant, anti-inflammatory, and cardiovascular protective effects for food ingredients
Ginseng Flowers Show Potential as Health Promoting Food Ingredients
This systematic review evaluates the phytochemical constituents and pharmacological activities of Panax ginseng flowers. The authors synthes…
Ginseng flowers contain specific compounds that may offer antioxidant and anti-inflammatory benefits in new food products like beverages.
Protein lactylation promotes tumor cell malignancy and drives immune evasion in the tumor microenvironment
Protein lactylation may fuel cancer growth and immune evasion
This systematic review examines the role of protein lactylation (Kla) in cancer progression and immunosuppression within the tumor microenvi…
A new review suggests that a protein modification called lactylation helps tumors grow and hide from the immune system.
101-PGC-005 achieves HR 2.31 for faster WHO scale improvement over dexamethasone in COVID-19
New drug beats dexamethasone for moderate COVID-19 recovery
This randomized Phase II/III trial of 309 hospitalized patients with moderate COVID-19 found that 101-PGC-005 (20 mg IV daily for 3 days) si…
A new drug helped hospitalized COVID-19 patients recover a day faster than dexamethasone, with similar safety.
Programmed cell death pathways form a spatiotemporally regulated network driving tubular damage in renal IRI
New research identifies key pathways driving acute kidney injury
This systematic review examines the roles of pyroptosis, ferroptosis, cuproptosis, and necroptosis as key mediators of inflammation and oxid…
Researchers have mapped out a complex network of cell death pathways that drive inflammation and damage in patients with acute kidney injury…
Anti-PD-1 based chemo-immunotherapy for nasopharyngeal carcinoma yields objective response rates of 20 to 91 percent
New Research Explores Treatments for Nasopharyngeal Carcinoma
This narrative synthesis reviews 182 studies regarding the mechanisms and treatments for nasopharyngeal carcinoma. It highlights that anti-P…
New research explores how immunotherapy and targeted treatments can improve outcomes for patients with nasopharyngeal carcinoma.
LDHA promotes malignant progression and drug resistance while modulating tumor-infiltrating immune cell differentiation
New research identifies LDHA as a promising target for cancer
This systematic review examines the role of Lactate dehydrogenase A (LDHA) in malignant tumors and its impact on the immune microenvironment…
A specific protein called LDHA helps tumors grow and resist drugs, making it a potential new target to combine with existing immunotherapies…
Natural anti-inflammatory products modulate the FOXP3-C5aR1-LIF axis to potentially manage chronic rhinosinusitis
Natural Compounds May Help Manage Chronic Rhinosinusitis Symptoms
This systematic review examines natural anti-inflammatory compounds including epigallocatechin-3-gallate, curcumin, and rosmarinic acid in t…
Certain natural anti-inflammatory products like curcumin and bromelain may help manage the immune response in people with chronic sinusitis.
scTCR/BCR-seq enables identification of pathogenic clones and informs treatment response in autoimmune diseases
New Sequencing Methods Help Track Autoimmune Disease Progress
This systematic review examines the utility of scTCR/BCR-seq for analyzing immune cell dynamics in autoimmune disease. The analysis indicate…
Advanced cell sequencing can help doctors track how immune cells behave and predict how patients might respond to specific treatments.
Meningeal Immune System Offers New Target for Glioblastoma Immunotherapy
New approach targets the immune system to treat brain tumors
This systematic review explores how targeting the meningeal immune system, including dural lymphatics and rBAMs, could overcome current barr…
A new strategy focuses on the area where brain tumors meet the body's defenses to improve how immunotherapy works for glioblastoma.
Circular RNAs may regulate ferroptosis and anti-tumor immunity in cancer via multiple mechanisms
Circular RNAs may offer new ways to target cancer cells
This systematic review explores how circular RNAs (circRNAs) act as molecular bridges to simultaneously regulate ferroptosis and anti-tumor …
New research identifies circular RNAs as molecular bridges that could help doctors diagnose and treat cancer more precisely.
FDA Approves Exdensur for Add-On Maintenance Treatment of Severe Eosinophilic Asthma
FDA approves new long-acting shot Exdensur for severe asthma.
FDA approved Exdensur (IL-5 antagonist) for add-on maintenance treatment of severe eosinophilic asthma in patients aged 12 years and older. …
The FDA approved Exdensur as an add-on treatment for severe asthma in people 12 and older. It is given as a shot every six months. This new …
All Allergy & Immunology Articles
- Solid organ transplant recipients face higher cancer-related mortality with SMR 2.21 across multiple organs
- Panax ginseng flower phytochemicals demonstrate antioxidant, anti-inflammatory, and cardiovascular protective effects for food ingredients
- Protein lactylation promotes tumor cell malignancy and drives immune evasion in the tumor microenvironment
- Programmed cell death pathways form a spatiotemporally regulated network driving tubular damage in renal IRI
- 101-PGC-005 achieves HR 2.31 for faster WHO scale improvement over dexamethasone in COVID-19
- Anti-PD-1 based chemo-immunotherapy for nasopharyngeal carcinoma yields objective response rates of 20 to 91 percent
- Natural anti-inflammatory products modulate the FOXP3-C5aR1-LIF axis to potentially manage chronic rhinosinusitis
- LDHA promotes malignant progression and drug resistance while modulating tumor-infiltrating immune cell differentiation
- scTCR/BCR-seq enables identification of pathogenic clones and informs treatment response in autoimmune diseases
- Circular RNAs may regulate ferroptosis and anti-tumor immunity in cancer via multiple mechanisms
- Meningeal Immune System Offers New Target for Glioblastoma Immunotherapy
- FDA Approves Exdensur for Add-On Maintenance Treatment of Severe Eosinophilic Asthma
- CD8+ T cells and associated signaling pathways influence osteoclast formation and osteoblast differentiation in osteoporosis
- E3 ubiquitin ligases modulate SARS-CoV-2 replication and immune evasion through targeted protein degradation mechanisms
- Rare overlap of myasthenia gravis and Kennedy's disease identified in case report
- Mechanism-based strategies including CAR-T and bispecific engagers offer options for rituximab-resistant primary membranous nephropathy
- Multitarget designs and microenvironment remodeling may overcome resistance to CAR T-cell therapy in B-cell malignancies
- System-level strategies and task-shifted care improve equity in global allergic disease management
- Dysregulation of the TOX/TCF-1 axis and IDH-mutation driven silencing drive cytotoxic failure in glioblastoma
- Innovative diagnostic techniques improve risk stratification and specificity in food allergy diagnosis
- Mucus-barrier regulatory programs in Crohn's disease and ulcerative colitis involve ER stress and microbial sensing
- Staphylococcal infections may mimic paradoxical psoriasis in patients receiving TNF-alpha inhibitors for systemic conditions
- Casirivimab plus imdevimab reduced risk of hospitalization or death in patients with and without asthma
- Gut eosinophils emerge as central regulators of intestinal homeostasis and immunity
- Maternal free vitamin D linked to offspring asthma risk
- Global allergy research grows 7.59% annually but risk-factor studies dominate, burden data scarce
- NF-κB signaling integrates mechanical stress and immunity in osteoarthritis joint degeneration
- Artificial intelligence as a mechanistic microscope and digital twin in colorectal cancer faces generalizability and regulatory validation limitations
- Endothelial ferroptosis blockade targets ischemic stroke and neurodegenerative conditions in brain microvascular endothelial cells
- CAR technology for autoimmune disorders, infectious diseases, fibrotic lesions, inflammatory bowel disease, and type 1 diabetes is reviewed
- Higher pan-immune-inflammation value linked to worse outcomes after PCI for ACS
- 1 514 781 patients shows methylisothiazolinone allergy prevalence is 5.48% in dermatitis cases
- Tumor occurrence was 25% in patients with anti-mGluR5 autoimmune encephalitis, higher in Western than Chinese patients
- Modulation of neutrophil function and death in critically ill patients with sepsis is discussed in this narrative review
- Immunotherapy and metabolic-targeted drug combination shows promise for osteosarcoma treatment
- Narrative review discusses cerebral small vessel disease without reporting specific interventions or outcomes
- Erratum published for vaccine recommendations report
- Biologic and targeted synthetic DMARDs show reassuring malignancy safety in inflammatory arthritides, but non-melanoma skin cancer risk rises with TNF inhibitors
- Ultrasound-driven mechanical immunomodulation shows promise for tumor therapy but faces key hurdles
- Combination therapy with 3M-052 and anti-TNFR2 antibody suppressed colon cancer growth in mouse models while enhancing immune response
- HLA-DPA1 and HLA-DPB1 expression is downregulated in pediatric asthma with high diagnostic value
- Chemo-immunotherapy yields 12-month disease-free status in rare triple-negative neuroendocrine breast cancer
- scFv-based biologics show potential for immunomodulation in type 1 and type 2 diabetes
- Periodontitis and chronic liver disease linked through proposed oral-gut-liver axis
- Combining immunoglobulins and cytokine levels could predict allergen-specific immunotherapy effectiveness
- Glycolysis-centered understanding of ovarian cancer may support biomarker-guided combination strategies and improve translational therapeutic design
- Multispecies animal models often fail to reflect human nasal sinus anatomy and physiology in chronic rhinosinusitis research
- Extracellular vesicle signalling may participate in postoperative neurocognitive disorder progression in older surgical patients
- Epstein–Barr virus infection shows higher seropositivity and viral loads in systemic lupus erythematosus patients compared to healthy controls
- Follicular T cell subsets and tertiary lymphoid structures may guide immunotherapy in ovarian cancer
- Tertiary lymphoid structures represent a promising but context-dependent biomarker and potential therapeutic intermediate in breast cancer
- Prenatal beta-2-adrenergic agonist exposure linked to increased ASD risk with aOR 1.34 preconception
- PD-1/PD-L1 inhibitors plus chemotherapy improve survival in advanced endometrial cancer
- Botulinum toxin type A improves nasal symptoms in refractory allergic rhinitis with SMD -2.07 at 4 weeks
- Transitioning from static TNM staging to a multidimensional, adaptive treatment model integrating genomics and immunology for HPV-associated OPSCC
- Immune checkpoint inhibitors appear safe in cancer patients with pre-existing sarcoidosis
- New HAE subtypes involving endothelial dysfunction support biomarker discovery and therapeutic strategies to stabilize the vascular barrier
- Antibody-based therapies offer potential efficacy and durability options for relapsed refractory acute myeloid leukemia patients
- Chronic HCV infection drives T cell dysfunction, regulatory T cell accumulation, and metabolic defects that persist after viral clearance
- Kounis syndrome shows male predominance 75 percent and 4 percent mortality in systematic review
- Telemedicine strategies improve asthma control and quality of life in adults
- Tumor Treating Fields may disrupt tumor communication and induce conditional BRCAness in malignant pleural mesothelioma
- Lactate-driven lactylation and acidification reshape tumor immunity in the TME
- High tumor extracellular matrix stiffness in solid tumors drives immune suppression and therapy resistance via YAP1
- Probiotics reduce nasal and eye symptom scores in children with allergic rhinitis
- Boron neutron capture therapy combined with immunotherapy may enhance anti-tumor response and transform the tumor microenvironment
- AI technologies for immunotherapy optimization face data quality and safety concerns hindering routine clinical adoption
- TLS manipulation and immunotherapy in pancreatic cancer face significant mechanistic and regulatory uncertainties
- Immunotherapies beyond rituximab show high response rates in diffuse large B-cell lymphoma
- CD38+ NK cells may link disrupted immune tolerance in rheumatoid arthritis and colorectal cancer
- Stimulus-responsive sonodynamic immunotherapy shows promise in preclinical cancer models
- Prior Exorchis infection blocks S. japonicum in snails: a narrative review
- Narrative review explores HNRNPA2B1 as a possible regulator of RNA fate in cancer
- Narrative review on KMT2C alterations in gastrointestinal cancers and therapeutic implications
- Narrative review on machine learning for immunogenicity risk assessment in preclinical research
- Review of T cell engagers highlights potential for treating solid tumors and small cell lung cancer cases
- Systematic review links viral infections to persistent and chronic urticaria in children and adults
- Narrative review discusses inflammaging and immunosenescence in older adults with colorectal cancer
- Systematic review finds vitamin D supplementation offers no lung function benefit for children with asthma
- Systematic Review of Macrophage Polarization in Osteosarcoma Immunotherapy
- Case report and review on autoimmune nodopathy with Sjogren's disease and nephrotic syndrome
- Observational study links ADAM9 expression to survival in lung adenocarcinoma patients
- Narrative review of extracellular vesicles for atopic dermatitis notes significant methodological gaps and safety data limitations
- Review: Targeting mRNA Processing Enhances Immune Checkpoint Blockade in Cancer
- Narrative review proposes time window framework for post-infarction ventricular remodeling intervention
- Meta-analysis finds ADHD linked to asthma but no causal effect in children
- Speleotherapy improves asthma control and breathing patterns in patients with respiratory conditions
- Meta-analysis of micronutrient supplementation for immune function in older adults
- FDA Approves Children's Claritin (loratadine) for Allergic Rhinitis Symptoms
- FDA Approves Xyzal Allergy 24hr (levocetirizine) for Hay Fever and Respiratory Allergy Symptoms
- Review of platelet extravasation without reported outcomes or safety data
- Review of lifestyle factors linked to Type 2 Diabetes risk in Qatar
- COPD guideline proposes cellular phenotype classification for targeted therapy
- Review of alpha-gal syndrome highlights tick bite link and knowledge gaps
- Narrative review discusses colorectal cancer metastasis patterns with immune checkpoint inhibitors and targeted therapies
- Narrative review examines metabolic syndrome and novel agents in kidney transplant recipients
- Molecular review explores Siglec signaling pathways in cancer and inflammatory disorders
- Systematic review and meta-analysis of resveratrol for spinal cord injury in animal models
- Narrative review highlights diagnostic gaps for house dust mite allergy in tropical regions
- Living systematic review finds low-certainty evidence that stopping csDMARDs before surgery may increase flare risk in inflammatory arthritis
- Meta-analysis of upadacitinib for rheumatoid arthritis finds similar efficacy for 15 mg and 30 mg doses
- FDA Approves Fasenra (benralizumab) for Severe Eosinophilic Asthma and EGPA
- Narrative review discusses extracellular vesicles as biomarkers for cancer, neurological disorders, and cardiovascular diseases
- Narrative review on tumor antigen-associated autoantibodies in cancer diagnosis and treatment
- Narrative review discusses antibody targeting of the TNF–TNFR2 axis in cancer with noted limitations
- Case report and review: IVIg and efgartigimod in Guillain-Barré with Graves disease and thyroid cancer
- Narrative review discusses CD40/CD40L signaling regulation in rheumatoid arthritis and other autoimmune conditions
- Review of antiviral and immunotherapeutic strategies for chronic hepatitis B
- Review synthesizes Treg biology and NB-UVB, JAK inhibitors, IL-2 in vitiligo patients
- Commentary on plateau in lupus nephritis trials and path to precision medicine
- Systematic review finds convalescent plasma does not reduce mortality in COVID-19
- Ven-Chi-Dec Regimen Induces Remission in Refractory Hodgkin Lymphoma
- Immediate smoking cessation support increases 12-month quit rates in adults with chronic airway diseases
- Immunocompetent tumor-on-a-chip platforms offer essential tools for understanding cancer-immune biology and accelerating personalized immunotherapy development
- Review discusses metabolic reprogramming of macrophages for sepsis-associated acute lung injury with noted limitations
- Narrative review of Europe-licensed anti-asthmatic biologics for severe pediatric asthma notes limited pediatric evidence
- Systematic review and meta-analysis of adherence to intranasal corticosteroids and oral antihistamines in adults with allergic rhinitis
- Bayesian network meta-analysis of first-line immunotherapy versus TKI for advanced hepatocellular carcinoma
- Case report and review: azacytidine plus ruxolitinib in connective tissue disease with CMML and myelofibrosis
- Review of methionine manipulation in solid tumor immunotherapy settings
- Review of Chinese yam polysaccharides highlights safety gaps and need for further research
- Systematic review and meta-analysis on cold air bronchial challenge test for asthma diagnosis
- Narrative review discusses cellular immunotherapy strategies for cholangiocarcinoma with noted limitations
- Narrative Review Explores Post-Stroke Immunosuppression in Ischemic Stroke
- Review reframes COPD therapy toward integrated death program modulation by inflammatory endotype
- Review highlights translational potential of beta-blockers and neurotrophin inhibitors in cancer treatment
- Review of neutrophil extracellular traps in patients with gout
- Meta-analysis on SPG acupuncture for allergic rhinitis quality of life and symptom scores
- Meta-analysis shows dual ICI therapy improves survival in advanced metastatic non-small cell lung cancer
- Review outlines immunotherapy roadmap for gastric cancer patients with noted limitations
- Systematic review of AI applications for protein misfolding diseases
- Narrative review discusses therapeutic cancer vaccines and their potential role in future clinical paradigms
- Review: Pregnane X Receptor Regulates Intestinal Homeostasis in Inflammatory Bowel Disease
- Review links mature intra-tumoral TLS to better prognosis and immunotherapy response in head and neck cancer
- Overlapping IgG4-Related Nephritis and ANCA Glomerulonephritis in Elderly Woman
- Network meta-analysis reveals induction immunochemotherapy plus CCRT improves survival for unresectable esophageal cancer patients compared to CCRT alone
- Review of metabolism-driven acylation modifications in COPD pulmonary cells
- Narrative review explores succinylation roles in cancer biology and tumor heterogeneity
- Review of immune checkpoint inhibitor-associated diabetes mellitus in two patients
- Review examines mRNA vaccines versus traditional platforms for colorectal cancer
- Systematic review and meta-analysis shows high atopic dermatitis prevalence in Ethiopia across regions
- Narrative review of isothermal amplification techniques for diagnostics in livestock and companion animals
- Review of SPMs for stroke notes promising neuroprotective effects with delivery limitations
- Narrative review on renal involvement in primary Sjögren's disease and therapeutic prospects
- Narrative review discusses Treg therapy for non-malignant diseases with noted limitations
- Systematic review and meta-analysis shows moderate correlation between S. aureus colonization and atopic dermatitis severity
- Systematic review of neurological manifestations in Wiskott–Aldrich syndrome
- Narrative review explores Vaccinia virus therapy for non-small cell lung cancer with noted delivery challenges
- Meta-analysis identifies key risk factors for food allergy in young children
- Review of epigenetic dysregulation in nasopharyngeal carcinoma management
- Switching Biologics in Severe Asthma Patients Shows Improved Clinical Outcomes and Reduced Exacerbations Across Multiple Therapies
- Case report of obinutuzumab-induced acute bicytopenia in autoimmune disease
- Narrative review discusses HPV-associated head and neck and cervical squamous cell carcinoma without reporting specific outcomes
- Montelukast and oral antihistamines improve daytime allergic rhinitis symptoms
- Meta-analysis shows increased risk of female sexual dysfunction in women with systemic lupus erythematosus
- Meta-analysis finds high prevalence of allergy, eosinophilia, and hyper-IgE in IgG4-RD
- Systematic bibliometric analysis reveals evolving research trends in DNGR-1 tumor immunology
- Resistance Training with Photobiomodulation Improves Muscle Strength in Difficult-to-Control Asthma
- Combination TACE plus systemic therapy showed no PFS benefit but improved OS in BCLC-C HCC patients compared to TACE alone
- Global MS burden in women of childbearing age rises 48% from 1990 to 2021
- Modified prednisone regimen shows short-term ineffectiveness in infantile epileptic spasms syndrome based on retrospective cohort data
- Review of ovarian cancer treatments including olaparib, bevacizumab, and durvalumab discusses limitations and biomarkers
- Emergency-use spacers improve salbutamol delivery in asthmatics compared to pMDI alone
- Repeated counseling with pMDI devices reduced inhalation errors in adult asthma patients compared to pMDI alone
- Montelukast vs Tiotropium Added to ICS in Children With Asthma
- Nurse-led rehabilitation consultation improves asthma control in primary care
- New propellant HFA-152a in BDP/FF/G pMDI shows similar efficacy to HFA-134a in asthma
- Systematic review and meta-analysis links swimming pool attendance to increased asthma risk in children
- Meta-analysis finds childhood asthma linked to higher risk of obstructive sleep apnea
- Inactivated SARS-CoV-2 vaccine dosing schedules and antibody responses in adults aged 60 to 80 years
- Th17/Treg ratios and cytokine levels associated with infection risk after kidney transplantation
- Systematic review identifies dual role of NLRP3 inflammasome in sepsis induced immune dysregulation
- Bayesian network meta-analysis compares exercise modalities for systemic inflammation in postmenopausal women
- Meta-analysis compares infection rates of teclistamab in clinical trials and real-world evidence
- Meta-analysis shows exercise interventions impact TNF-alpha but not IL-6 or CRP in older adults
- Case report and literature review of severe adverse reactions following pucotenlimab treatment
- Web-based tool improves phenotype capture for Common Variable Immunodeficiency in UK cohort
- Narrative review discusses Chikungunya virus infection without reporting specific clinical data or outcomes
- Systematic review outlines theoretical basis for early warning and personalized treatment in IgAVN
- Review of engineered exosomes for knee osteoarthritis notes significant limitations and lack of efficacy data
- Systematic review and meta-analysis of stem cell therapy for dry eye in Sjögren's syndrome
- Consolidation immunotherapy shows no survival benefit over induction alone in stage III non-small cell lung cancer
- Disitamab vedotin plus PD-1 inhibitor showed high response rates in urothelial carcinoma patients across six centers
- Single-center study finds 42.70% allergen sensitization rate in children in Kashi Prefecture
- Lanadelumab reduced attacks in Chinese adults with hereditary angioedema over six months
- Review examines thoracic radiotherapy combined with chemoimmunotherapy for extensive-stage small cell lung cancer patients
- Review discusses translational potential of macrophage-state signatures for atherosclerosis risk stratification and therapeutic targeting
- Systematic review on allergic rhinitis links environmental exposures and microbiome changes
- Meta-analysis shows pharmaceutical care improves asthma and COPD management outcomes in 4173 patients
- High NEK6 expression linked to poor colorectal cancer prognosis and glycolytic subtype dominance
- Multimodal fusion model predicts pathological complete response in 262 breast cancer patients receiving neoadjuvant therapy
- Retrospective Cohort Finds Elevated NLR and PLR Associated with Complications and Survival in Hepatocellular Carcinoma
- Elevated hs-CRP associates with airflow limitation and PRISm in 335 adult liver transplant recipients
- Narrative review discusses eosinophil abundance associations with lung cancer prognosis and immunotherapy response
- Systematic review identifies 16 mRNA vaccine antigens for pancreatic cancer immunotherapy
- Mini-review explores oxidized mannan-conjugated MOG peptide for multiple sclerosis immunotherapy
- Systematic review and meta-analysis of ENA seropositivity in ANA-IIF-negative connective tissue disease populations
- Narrative review explores pattern recognition receptor signaling roles in pediatric otitis media management
- Narrative review outlines miRNA-based strategies and challenges in pancreatic ductal adenocarcinoma management
- Systematic review on tertiary lymphoid structures in hepatocellular carcinoma