This week's Neurology digest · 2026-W19
This Week in Neurology: Stroke Interventions and Schizophrenia Findings
Evaluating High Frequency Repetitive Transcranial Magnetic Stimulation for Post Stroke Cognitive Impairment
Magnetic brain stimulation may improve memory after a stroke
Meta-analysis results indicate that HF-rTMS significantly improves various memory functions in patients suffering from post-stroke cognitive…
A large review of data suggests that high-frequency magnetic stimulation could help improve memory for people living with post-stroke cognit…
Efficacy of Levodopa Based Therapy for Motor and Cognitive Recovery After Stroke
Levodopa does not improve movement after a stroke
A meta-analysis involving 1,257 patients found that adding levodopa to standard stroke rehabilitation yields no significant improvement in m…
A large review of stroke recovery shows that adding levodopa to rehabilitation does not improve physical movement, mood, or thinking.
EEG microstate duration and occurrence rates differ significantly between Alzheimer's patients and healthy controls
Brain wave patterns show differences in Alzheimer's and memory loss
This meta-analysis of 16 studies evaluated EEG microstate parameters in patients with Alzheimer's disease (AD) and mild cognitive impairment…
New analysis shows specific brain wave patterns change as memory fades, offering a new way to look at how the brain handles information.
Plasma p-tau217 and Aβ42/40 biomarkers show high AUC for discriminating amyloid PET positivity
Blood Tests May Help Identify Early Signs of Alzheimer's
This meta-analysis of 9 studies involving 2566 cognitively unimpaired Asian individuals found that plasma p-tau217 (AUC 0.88) and Aβ42/40 (A…
New research shows that specific blood markers can help identify early signs of amyloid buildup in the brain for people without memory loss.
Resistance training improves quality of life in Parkinson's disease, meta-analysis finds
Resistance training improves quality of life for Parkinson's disease
This meta-analysis found that resistance training improves quality of life in Parkinson's disease compared to control (SMD -0.81, CI -1.45 t…
New data shows that resistance training helps people with Parkinson's disease enjoy a better quality of life compared to no exercise.
194 miRNAs exhibit widespread changes in Alzheimer's disease and influence key biological pathways
194 microRNAs show widespread changes in Alzheimer's disease
This meta-analysis of 22 studies identifies 194 miRNAs with widespread changes in Alzheimer's disease. The analysis highlights the involveme…
A meta-analysis of 22 studies found 194 microRNAs with widespread changes in Alzheimer's disease, including novel ones. These miRNAs affect …
Dual antiplatelet therapy reduces stroke recurrence in patients with acute mild ischaemic stroke
Dual Antiplatelet Therapy Reduces Stroke Risk in Mild Cases
This meta-analysis evaluated dual antiplatelet therapy compared to monotherapy in patients with acute mild ischaemic stroke or TIA. The anal…
New data shows dual antiplatelet therapy can lower stroke recurrence for patients with mild ischemic strokes or TIA, despite higher bleeding…
Multiple factors including advanced age, hemorrhage, and ventilation duration predispose patients to post-traumatic hydrocephalus
Risk Factors Linked to Hydrocephalus After Brain Injury
This narrative review synthesizes risk factors for post-traumatic hydrocephalus in patients with traumatic brain injury. Key findings includ…
Certain factors like advanced age, severe brain injury, and specific surgical procedures may increase the risk of hydrocephalus after a head…
Cocaine and amphetamine use significantly increase stroke risk as confirmed by Mendelian randomization
Drug use linked to higher risk of stroke in large study
This systematic review and meta-analysis of 32 studies involving over 100 million participants evaluates the impact of substance use on stro…
New data from over 100 million people shows that using drugs like cocaine and amphetamines significantly increases the risk of having a stro…
Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
Atrial Fibrillation Linked to Stroke Risk After Brain Bleed
This systematic review and meta-analysis of 198,289 adults with intracerebral hemorrhage (ICH) identifies an annual recurrence rate of 2.1% …
A large review of over 198,000 patients shows a significant link between atrial fibrillation and stroke risk following an intracerebral hemo…
Botulinum toxin reduces spasticity in adult stroke survivors but shows inconsistent benefits for gait and balance
Botulinum Toxin Reduces Spasticity in Adult Stroke Survivors
This meta-analysis of 1740 adult stroke survivors found that botulinum toxin is effective in reducing spasticity. However, the evidence for …
Botulinum toxin can reduce muscle stiffness after a stroke, though its impact on walking and balance remains inconsistent across different p…
Cladribine tablets reduce annualized relapse rate by 58% compared to placebo in active RRMS
Cladribine tablets show promise for managing relapsing-remitting multiple sclerosis
This systematic review and network meta-analysis of 66 studies evaluated cladribine against various disease-modifying treatments for relapsi…
New data shows cladribine tablets significantly reduce relapse rates and slow disease progression in people with active relapsing-remitting …
All Neurology Articles
- Multiple factors including advanced age, hemorrhage, and ventilation duration predispose patients to post-traumatic hydrocephalus
- 194 miRNAs exhibit widespread changes in Alzheimer's disease and influence key biological pathways
- Cocaine and amphetamine use significantly increase stroke risk as confirmed by Mendelian randomization
- Intracerebral hemorrhage survivors face annual rates of 2.1% recurrent ICH and 2.0% ischemic stroke
- Botulinum toxin reduces spasticity in adult stroke survivors but shows inconsistent benefits for gait and balance
- Efficacy of Levodopa Based Therapy for Motor and Cognitive Recovery After Stroke
- Evaluating High Frequency Repetitive Transcranial Magnetic Stimulation for Post Stroke Cognitive Impairment
- EEG microstate duration and occurrence rates differ significantly between Alzheimer's patients and healthy controls
- Plasma p-tau217 and Aβ42/40 biomarkers show high AUC for discriminating amyloid PET positivity
- Cladribine tablets reduce annualized relapse rate by 58% compared to placebo in active RRMS
- Optical coherence tomography shows significantly reduced retinal measurements in neuromyelitis optica spectrum disorder compared to multiple sclerosis
- Nabiximols reduces pain and spasticity in multiple sclerosis patients
- Resistance training improves quality of life in Parkinson's disease, meta-analysis finds
- Non-immersive virtual reality combined with conventional therapy improves upper limb function and activities of daily living
- Dual antiplatelet therapy reduces stroke recurrence in patients with acute mild ischaemic stroke
- Supratentorial location and intratumoral hemorrhage are common imaging features in DICER1-mutant primary intracranial sarcoma
- Non-pharmacological interventions show potential but uncertain cognitive benefits in TBI
- Inclinometer-based active joint repositioning is the most feasible tool for assessing lumbar proprioception
- Comprehensive intervention measures improve health literacy and self-management ability in patients with epilepsy
- Artificial Intelligence achieves Dice scores of 0.82-0.84 in tumor segmentation and AUC values of 0.80-0.90 for molecular prediction
- Serum neurofilament light chain serves as a robust biomarker of recent neuroaxonal injury in Multiple Sclerosis
- Transcranial Magnetic Stimulation reduces motor overflow in focal dystonia and improves stroke and cerebral palsy outcomes
- Diabetes mellitus acts as a context-dependent modifier of risk and phenotype in neurological disorders
- Sex-specific genetic risk loci and causal proteins in Parkinson's disease
- Amblyopia impacts reading speed, eye movements, and crowding in patients with binocular vision disorders
- Remote DWI lesions after intracerebral hemorrhage signal ischemic injury but mechanisms remain unclear
- AI-driven and traditional imaging markers provide a structured framework for predicting hematoma expansion in acute ICH
- Combined plasma p-tau217 and tau-PET identify high-risk patients with hazard ratios up to 9.98
- Structured exercise training improves motor performance and modulates TMS neurophysiological markers in healthy adults
- FDA Approves Belbuca (buprenorphine) Buccal Film for Severe Persistent Pain
- cGAS-STING signaling pathway activation drives inflammation, fibrosis, and functional decline in various kidney diseases
- DPP-4 inhibitors may reduce drug-resistant epilepsy risk via the gut microbiota and GLP-1 axis
- AhR signaling exhibits dual neurotoxic or neuroprotective effects depending on specific ligand types
- Transcutaneous auricular vagus nerve stimulation mechanisms and parameter optimization reviewed
- Multidimensional biomarker panels suggest a complex pathological basis for post-stroke depression in the DRN-mPFC circuit
- Acupuncture-related therapies significantly reduce overall, physical, and mental fatigue in chronic fatigue syndrome patients
- Intravenous thrombolysis does not improve excellent functional recovery in patients with minor acute ischemic stroke
- Transitional care interventions reduce rehospitalization and improve quality of life in adult stroke survivors
- FDA Approves Morphine Sulfate Oral Solution for Acute and Chronic Pain
- FDA Approves Xtampza ER (oxycodone) for Severe Persistent Pain
- FDA Approves OxyContin (oxycodone) for Severe Pain in Adults and Pediatric Patients
- FDA Approves Morphine Sulfate Tablets for Acute and Chronic Pain
- Transcutaneous auricular vagus nerve stimulation may improve autonomic balance and reduce visceral sensitivity in gastrointestinal disorders
- Neuroprotective anesthesia targets protocol aims to reduce silent brain infarction and perioperative neurocognitive disorders
- NfL serves as a sensitive biomarker for RRMS progression while GFAP lacks independent prognostic value
- Acoustic stimulation provides adjunctive analgesic value for managing acute and chronic pain conditions
- Ferroptosis-driven domino effect links disc degeneration to spinal cord injury
- Neuroinflammation-targeted immunotherapy shows no significant benefit in ischemic stroke meta-analysis
- FDA Approves Rextovy (naloxone) Nasal Spray for Opioid Overdose Emergency Treatment
- One Health approach in Chagas disease remains fragmented, review finds
- Transcatheter aortic valve replacement shows comparable mortality to surgery in severe symptomatic aortic stenosis
- Fecal microbiota transplantation improves motor function and constipation in patients with Parkinson disease
- Tenecteplase shows no significant difference in serious adverse event distribution compared to alteplase
- Vasospasm after thrombectomy may signal microvascular failure needing vasodilators
- MIPS and ES rank highest for functional outcomes in patients with spontaneous intracerebral hemorrhage
- PINGS intervention improves systolic blood pressure control to 67% compared to 43% in usual care
- rTMS interventions significantly reduce modified Ashworth Scale scores for post-stroke limb spasticity
- Safinamide 100 mg outperforms rasagiline 1 mg and zonisamide 25 mg for motor fluctuations
- Anterior location and complex trauma are associated with higher mortality in superior sagittal sinus injuries
- Long-term dual-task training may improve dynamic balance and functional independence in individuals with Down syndrome
- Rapid advancements in imaging and blood-based biomarkers are transforming the diagnosis and management of ADRD
- ACTH and vigabatrin achieved full seizure control in a patient with Ververi-Brady syndrome
- Aging impacts multiple sclerosis pathobiology by shifting inflammation toward chronic, compartmentalized neuroinflammation and neurodegeneration
- Tirofiban Adjunct Therapy Improves Outcomes in Patients with Inadequate Tenecteplase Response
- Immunometabolic dysregulation drives hyperalgesia and hypoesthesia in diabetic peripheral neuropathy
- Artificial intelligence shows potential for diagnosis, behavior analysis, and educational support in autism spectrum disorder
- Acupuncture shows consistent signals for dysphagia and depressive symptoms after ischemic stroke
- Brain-computer interface training improves global cognitive function in stroke survivors with SMD=0.62
- Exercise, microbiota, and tRNA modifications may influence mitochondrial function and proteostasis in Parkinson's disease
- Repetitive transcranial magnetic stimulation may enhance upper limb motor function following a stroke
- Transcarotid Artery Revascularization shows lower 30-day stroke and death risk compared to TF-CAS
- FDA Approves Vyepti (eptinezumab-jjmr) for Preventive Treatment of Migraine in Adults
- FDA Approves Epidiolex (cannabidiol) for Seizures Associated with LGS, DS, or TSC
- FDA Approves Ajovy (fremanezumab) for Preventive Migraine Treatment in Adults and Pediatric Patients
- FDA Approves Emgality (galcanezumab) for Preventive Treatment of Migraine and Episodic Cluster Headache
- Advanced experimental models and computational tools provide dynamic frameworks for understanding oral disease progression
- Menopause does not appear to be a distinct clinical inflection point for multiple sclerosis progression
- Traumatic BPPV triples recurrence risk versus idiopathic BPPV in meta-analysis of 4,074 patients
- Periodontal disease is associated with a 2.67 odds ratio for Alzheimer's disease
- Cardio-cerebral ion channel dysfunction links SUDEP and long QT syndrome in epilepsy patients
- MIND diet shows greater cognitive improvement in community-dwelling adults with high biomarker levels over three years
- Oral vitamin B12 reduces deficiency risk in children but shows little impact on growth or cognition
- Isolated hypoglossal nerve palsy from carotid dissection shows 65.6% favorable outcomes with medical management in 87 adult patients
- Meta-analysis shows tirofiban improves functional independence but raises intracranial hemorrhage risk in acute ischemic stroke patients
- Remote transitional care improves depressive symptoms in stroke patients, meta-analysis finds
- Ceramides emerge as key players in Alzheimer's pathology but therapeutic targeting faces hurdles
- Bipolar disorder is associated with a 3.65-fold higher risk of Parkinson's disease in six cohort studies
- Obesity in older adults lowers Alzheimer's risk while underweight status and weight loss increase it
- GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
- Delirium-directed interventions show mixed long-term cognitive outcomes in ICU survivors with acute respiratory failure
- Six novel loci and nine recessive loci identified for young onset Parkinson's disease in European ancestry
- Meta-analysis identifies 311 serum metabolite associations in Alzheimer's disease trajectory
- Triple Pill Therapy Lowers Recurrent Stroke Incidence in Patients With Prior Intracerebral Hemorrhage
- HMC3 microglial model illuminates neurodegenerative mechanisms and early therapeutic discovery
- IBD-related neuroimaging shows brain alterations in emotional networks with distinguishable phenotypes for Crohn's and ulcerative colitis
- TREM2 activation lowers amyloid plaques and tau in Alzheimer's disease animal models across twelve studies
- Adding quantitative FDG-PET interpretation improves specificity in Alzheimer's diagnosis
- Acupuncture Boosts Cognition in Alzheimer's and Mild Cognitive Impairment
- FDA Approves Morphine Sulfate Injection for Severe Pain Requiring Opioid Analgesic
- FDA Approves Soliris (eculizumab) for Generalized Myasthenia Gravis and NMOSD
- Ethanol exposure and high-fat diet may impair amyloid-beta clearance and promote oxidative stress in Alzheimer's disease
- Non-invasive brain stimulation with motor imagery improves upper limb function after stroke with WMD 5.75
- Thrombectomy plus intra-arterial alteplase increases excellent functional outcome to 57.5% at 90 days
- Aging is associated with poorer locomotor recovery after traumatic spinal cord injury in preclinical models
- Higher admission WBC predicts favorable methylprednisolone effect after thrombectomy
- Apixaban Reduces Intracranial Bleeding Risk Compared To Aspirin In Patients With Cryptogenic Stroke And Atrial Cardiopathy Evidence
- Post hoc analysis shows unsuccessful thrombectomy does not worsen outcomes for large ischemic infarcts compared to medical treatment alone
- QSM MRI reveals distinct iron deposition patterns differentiating Parkinsonian syndromes
- Systematic review finds inflammatory markers elevated in Alzheimer's disease compared to healthy controls across 41 studies
- Intracranial hemorrhage rates were higher in tenecteplase than standard care at 14.4% versus 9.2% in minor ischemic stroke
- Continuous subcutaneous foslevodopa/foscarbidopa improves off time in Parkinson's disease; severe adverse events higher in prior DBS group
- Endovascular therapy showed no benefit over medical care alone for mild-to-moderate medium or distal vessel occlusion stroke patients in this randomized trial
- Interactive cognitive-motor training improves mobility, gait, and balance in chronic stroke
- Noninvasive brain stimulation reduces pain intensity in central poststroke pain with a pooled effect size of -0.64
- Extended-window alteplase increases functional outcomes but raises hemorrhage risk in acute ischemic stroke patients
- Endovascular thrombectomy boosts functional independence significantly for acute ischemic stroke patients compared to medical management alone
- GBA1 L444P carriers have ninefold higher odds of Parkinson's disease than non-carriers
- Nurse-driven service model reduces door-to-needle time by 16.72 minutes in acute ischemic stroke
- Integrative brain care bundles and transdisciplinary training dismantle structural barriers in maternal-child health globally
- Robot-assisted gait training improves walking ability and functional independence in spinal cord injury
- T cell-microglial interactions drive aging and myelin changes in neurodegeneration models
- High-dose ocrelizumab 1200/1800 mg shows no significant difference in disability progression versus 600 mg in MS
- Ocrelizumab reduces disability progression risk in primary progressive multiple sclerosis versus placebo
- Prasinezumab showed non-significant delay in motor progression versus placebo in early-stage Parkinson's disease
- Oral Semaglutide Failed to Slow Clinical Progression in Early Alzheimer's Disease Across Global Phase 3 Trials
- Non-invasive neural stimulation improves upper limb function in subacute stroke: meta-analysis
- Genetic variants and environmental factors like PM2.5 exposure may increase asthma risk in susceptible individuals
- Network meta-analysis compares alteplase, tenecteplase, and JX10 for acute ischemic stroke treatment outcomes
- Sleep and circadian rhythm alterations associate with prolonged ventilation and worse outcomes in adult ICU patients
- Protocol outlines planned network meta-analysis of electromagnetic stimulation for post-stroke lower limb dysfunction
- Network meta-analysis of Tuina-based combination therapies versus oral medication for insomnia
- Asia-Pacific experts reach consensus on migraine management and anti-CGRP mAb use in adolescents
- Systematic Review: Flavonoids from Traditional Chinese Medicine Show Promise for NAFLD
- Review of glaucoma management without reported intervention details or outcomes
- Narrative review suggests music therapy may improve cognition and neuropsychiatric symptoms in cognitive impairment
- Systematic review and meta-analysis shows dual-task training improves motor function in cerebral palsy children
- Narrative review discusses MS continuum concepts for high-risk individuals
- Review of dopamine receptor targeting for chronic pain and mood disorders notes limited causal evidence
- Systematic review and meta-analysis of retinal biomarkers in frontotemporal dementia and Alzheimer disease
- Meta-analysis suggests specific rTMS protocols improve cognitive and functional outcomes in stroke survivors
- Meta-analysis of exercise for post-stroke cognitive impairment shows cognitive and motor benefits
- Observational study of autonomic responses in 51 dyads shows lower accuracy than self-report
- IV tenecteplase beyond 4.5 hours shows modest benefit but higher bleeding risk in acute ischemic stroke patients
- Ibudilast metabolomics in progressive multiple sclerosis brain atrophy trial
- FDA Approves Fintepla (fenfluramine) for Seizures in Dravet and Lennox-Gastaut Syndromes
- Network meta-analysis finds acupoint stimulation may improve function and fatigue in multiple sclerosis
- This narrative review examines immune-mediated thrombocytopenia and thrombotic thrombocytopenic purpura conditions without specific intervention data or reported outcomes
- Scoping review of factors affecting P100 latency and amplitude in healthy individuals
- Systematic review on EEG monitoring versus ICP in traumatic brain injury patients
- Combined motor and cognitive therapy shows mixed benefits in Parkinson's disease
- Network meta-analysis reviews acupuncture for post-stroke spasticity
- Meta-analysis finds higher peripheral Galectin-3 levels in cognitive impairment
- Systematic review of neural progenitor cell transplantation for spinal cord injury
- Bayesian network meta-analysis compares CGRP therapies for episodic migraine
- Systematic review and meta-analysis of engineered exosomes in preclinical Alzheimer's models
- MAD shows modest BP benefit over CPAP in OSA patients
- Meta-analysis finds probiotics modestly improve sleep quality with low certainty
- Systematic review and meta-analysis of ACT-based interventions for depression in stroke patients
- Review of ferroptosis role in postoperative cognitive dysfunction in older surgical patients
- Sensory cueing improves gait in Parkinson's disease patients
- Endovascular thrombectomy improves outcomes in large-core stroke within 24 hours
- Systematic review and meta-analysis of AI for post-stroke epilepsy prediction and diagnosis
- FDA Approves Onapgo (apomorphine) for Motor Fluctuations in Advanced Parkinson's
- Systematic review examines early erythropoiesis-stimulating agents for preterm infants across multiple clinical outcomes and safety endpoints
- Higher m-cSVD scores linked to increased stroke risk in hemorrhage-prone patients
- Telenursing review shows reduced COPD and asthma exacerbations and hospitalizations
- tDCS improves global cognition in Alzheimer's and MCI
- Restrictive platelet thresholds reduce transfusions without increasing death or bleeding risk in thrombocytopenic neonates
- Narrative review outlines multimodal decision-making for EGFR-mutant NSCLC with leptomeningeal metastasis
- Narrative review synthesizes neural activation patterns in the caudate nucleus and dorsal striatum during gustatory stimulation
- Narrative review links personality traits to Alzheimer's disease risk and cognitive outcomes
- Systematic review finds facial expression recognition shows promise for stroke diagnosis and rehabilitation monitoring
- Narrative review links exercise and sleep architecture to executive function in older adults
- Deep brain stimulation improves motor function and reduces levodopa needs in Parkinson's disease patients regardless of GBA mutation status
- Umbrella review synthesizes evidence on sexsomnia, a disorder of arousal from N2/N3 sleep
- Meta-analysis finds pharmacologic therapies improve RLS in hemodialysis patients
- Systematic review compares CEA, CAS, and TCAR for carotid artery stenosis stroke risk
- FDA Approves Mavenclad (cladribine) for Relapsing Forms of Multiple Sclerosis
- Meta-analysis finds remote ischemic conditioning modestly improves functional independence in acute ischemic stroke
- Narrative review offers qualitative synthesis without reported quantitative outcomes or safety data
- Protocol for a review on neurosurgical intervention versus conservative management in older adults with traumatic brain injury
- Stroke scale expansions improve posterior circulation deficit detection
- Repetitive transcranial magnetic stimulation shows promise for improving cognition and executive function in patients with mild cognitive impairment
- Narrative review proposes integrative monitoring framework for intracerebral hemorrhage
- Meta-analysis of Mendelian randomization suggests GLP-1 receptor agonism lowers vascular dementia risk
- Meta-analysis links mitochondrial polygenic score to alpha-synuclein seeding in LRRK2-related Parkinson's disease
- Individual patient data meta-analysis links blood neurofilament light chain levels to ischemic stroke outcomes
- Review of 2-AG and benzodiazepines for anxiety disorders highlights mechanistic gaps
- Comprehensive review examines nano-adjuvant technologies for poultry vaccines globally
- Review of ivermectin MDA for onchocerciasis and hookworm co-infections in endemic regions
- Narrative review discusses neurodegenerative diseases without reporting specific interventions or outcomes
- Exosome therapy reduces seizures and inflammation in preclinical epilepsy models: a meta-analysis
- AI-assisted PET radiomics improves Alzheimer's diagnosis over conventional methods in meta-analysis
- Tenecteplase linked to higher thrombus migration than alteplase in acute ischemic stroke with EVT
- Early dual antiplatelet therapy improves outcomes after ischaemic stroke thrombolysis
- Narrative review examines RNA editing alterations in Parkinson's disease patients
- Narrative review refutes causal link between endometriosis and migraine
- Glomerular Hyperfiltration Linked to Higher Mortality in Stroke and TIA Patients
- Systematic review and meta-analysis of intra-arterial tenecteplase after endovascular thrombectomy for acute ischemic stroke
- FDA Approves Vyvgart Hytrulo (efgartigimod alfa/hyaluronidase) for CIDP and gMG