This week's Oncology digest · 2026-W19
This Week in Oncology: Lymphoma Responses and Breast Cancer Survival
Intracranial immunotherapy delivery does not improve survival for pediatric high-grade glioma compared to systemic administration
Intracranial Delivery Shows Higher Neurotoxicity Risk in Pediatric Brain Tumors
This meta-analysis of 22 studies evaluated intracranial versus systemic immunotherapy delivery in pediatric patients with high-grade and dif…
New analysis shows that while delivery methods do not change survival for pediatric brain tumors, some routes carry a higher risk of severe …
PD-1 inhibitors plus chemotherapy achieve 64% objective response rate in recurrent or metastatic nasopharyngeal carcinoma
Different PD-1 Inhibitors Show Varying Results for Nasopharyngeal Cancer
This systematic review and meta-analysis of 1,459 patients with recurrent or metastatic nasopharyngeal carcinoma found a pooled objective re…
A review of 1,459 patients shows that different PD-1 inhibitors combined with chemotherapy offer varying survival and response rates for nas…
Combination strategies using DNA damage response inhibitors aim to overcome resistance in pancreatic cancer
New combination strategies aim to treat pancreatic cancer more effectively
This systematic review evaluates DNA damage response (DDR) inhibitors, including monotherapy and combination regimens, for pancreatic cancer…
Combining different drugs could help overcome treatment resistance and reach more patients with pancreatic cancer.
Radiomics-based machine learning achieves high AUROC for preoperative risk stratification in bladder cancer
Machine Learning May Help Identify Risks in Bladder Cancer
This systematic review and meta-analysis of 57 studies involving 11,933 participants evaluated radiomics-based machine learning for preopera…
New analysis shows machine learning can help identify muscle invasion and tumor grades in patients with bladder cancer using imaging data.
Specific clinical and radiological features may identify risk for leptomeningeal dissemination in oligodendroglioma
Risk Markers Linked to Spread of Oligodendroglioma in Spinal Fluid
This scoping review of 15 studies identifies several indicators associated with leptomeningeal dissemination (LMD) in patients with oligoden…
Identifying specific markers like high Ki-67 levels and ventricular involvement may help doctors track the spread of certain brain tumors.
HOX gene dysregulation influences cellular processes but currently lacks utility as reliable HNSCC biomarkers
HOX genes play complex roles in head and neck cancer
This mini-review examines the role of HOX genes in head and neck squamous cell carcinoma (HNSCC). The authors conclude that while these gene…
New research highlights how HOX genes drive tumor growth and survival in head and neck cancers, though their use as clinical tools is still …
Sacubitril/Valsartan preserves left ventricular systolic function and attenuates GLS deterioration during chemotherapy
Sacubitril and Valsartan May Protect Heart Function During Chemotherapy
This meta-analysis of randomized controlled trials evaluates sacubitril/valsartan for patients undergoing chemotherapy to manage chemotherap…
A new review suggests the medication sacubitril/valsartan may help preserve heart muscle function for patients undergoing chemotherapy.
Comprehensive palliative care improves quality of life, survival, and symptoms in thoracic cancer patients
Palliative care improves quality of life for thoracic cancer patients
This meta-analysis of 6490 people with thoracic cancer found that comprehensive palliative care interventions improved quality of life (SMD …
Comprehensive palliative care can improve survival, manage symptoms, and boost quality of life for people living with thoracic cancers.
MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
MRI Radiomics Help Predict TERTp Mutation in Glioma Patients
Meta-analysis of 14 studies shows MRI radiomics predicts TERTp mutation in glioma with AUC 0.79; combined models improve accuracy to 0.82.
New analysis shows MRI-based radiomics can help predict specific genetic mutations in glioma, potentially aiding early diagnosis and treatme…
Cisplatin-based chemotherapy associated with superior survival over carboplatin in advanced bladder cancer
Cisplatin shows better survival for patients with bladder cancer
This meta-analysis of 2543 patients found that cisplatin-based regimens are associated with significantly better overall survival and cancer…
New data reveals that cisplatin-based chemotherapy leads to longer survival than carboplatin for many people with advanced bladder cancer.
DaVinci Single-Port transoral robotic surgery is feasible across multiple indications including oncology and sleep apnea
Single-Port Robot Shows Promise for Sleep Apnea Surgery
This systematic review and meta-analysis of 479 patients evaluates the feasibility of DaVinci Single-Port (SP) transoral robotic surgery (TO…
A new analysis finds single-port robotic surgery for sleep apnea is feasible, with short operating times and low blood loss.
Neoadjuvant chemoimmunotherapy achieves higher pathological complete response rates than chemotherapy alone in muscle-invasive bladder cancer
Chemoimmunotherapy Shows Higher Response Rates in Bladder Cancer
This network meta-analysis of 2234 patients with muscle-invasive bladder cancer compares neoadjuvant chemoimmunotherapy (NICT), chemotherapy…
A new analysis shows that combining chemotherapy and immunotherapy may lead to higher response rates for patients with muscle-invasive bladd…
All Oncology Articles
- Intracranial immunotherapy delivery does not improve survival for pediatric high-grade glioma compared to systemic administration
- Radiomics-based machine learning achieves high AUROC for preoperative risk stratification in bladder cancer
- HOX gene dysregulation influences cellular processes but currently lacks utility as reliable HNSCC biomarkers
- Specific clinical and radiological features may identify risk for leptomeningeal dissemination in oligodendroglioma
- PD-1 inhibitors plus chemotherapy achieve 64% objective response rate in recurrent or metastatic nasopharyngeal carcinoma
- Combination strategies using DNA damage response inhibitors aim to overcome resistance in pancreatic cancer
- Sacubitril/Valsartan preserves left ventricular systolic function and attenuates GLS deterioration during chemotherapy
- DaVinci Single-Port transoral robotic surgery is feasible across multiple indications including oncology and sleep apnea
- Neoadjuvant chemoimmunotherapy achieves higher pathological complete response rates than chemotherapy alone in muscle-invasive bladder cancer
- MRI Radiomics Predicts TERTp Mutation in Glioma with Moderate Accuracy
- Comprehensive palliative care improves quality of life, survival, and symptoms in thoracic cancer patients
- Cisplatin-based chemotherapy associated with superior survival over carboplatin in advanced bladder cancer
- FDA Approves Voranigo (vorasidenib) for IDH-Mutant Grade 2 Glioma
- AZA or LDAC combined with venetoclax likely improves mortality, remission, and quality of life
- Hepatic MPNST without NF1: normal tumor markers, no recurrence 2 years after resection
- Signet ring morphology in gastric biopsies may mask metastatic invasive lobular carcinoma from breast cancer
- Tucatinib plus trastuzumab and pertuzumab improves median PFS to 24.9 months in HER2+ MBC
- THP shows noninferior pCR rates compared to TCbHP in HER2-positive invasive breast cancer
- Epigallocatechin-3-gallate shows positive therapeutic effects on various digestive system diseases in animal models
- PGA sheets plus fibrin glue reduce delayed bleeding risk after gastric endoscopic submucosal dissection
- Combined pelvic and para-aortic lymphadenectomy improves overall survival compared to no lymphadenectomy in endometrial cancer
- Postoperative lymphocele affects 30% of gynecologic cancer patients after lymph node dissection
- Orthotopic neobladder techniques show comparable functional outcomes in bladder cancer
- Robotic cholecystectomy shows fewer complications and shorter hospital stay for gallbladder cancer
- EMR integrated platform improves data abstraction efficiency and speed for cancer patient records
- Advanced MR neurography and 3D modeling provide supplemental preoperative planning for facial nerve assessment in parotid tumors
- TRAM MRI shows 0.89 AUC for differentiating treatment response from radionecrosis in CNS tumors
- CIK/DC-CIK cell therapy plus chemotherapy improves overall survival in patients with gastric cancer
- Bibliometric analysis maps research trends and key contributors in immune checkpoint inhibitors for endometrial cancer
- Modified pectoral plane block (PECS II) provides longer analgesia duration and lower morphine use
- ctDNA positivity linked to increased risk of brain metastases in advanced solid tumors
- Vascular smooth muscle cell immune interactions drive remodeling across cardiovascular diseases
- Meta-analysis shows sublobar resection linked to worse survival outcomes compared with lobectomy for early-stage non-small cell lung cancer patients
- E-health self-management interventions improve quality of life in cancer patients with a standardized mean difference of 0.18
- Large energy acceptance beam delivery systems may enable ultra-fast treatment within 10 seconds compared to conventional systems
- Screening and management strategies for stigma in patients with colorectal cancer and stomas require clinically meaningful guidance
- Diagnostic prediction models show moderate-to-good discrimination for cancer-related fatigue
- Intrathecal chemotherapy via Ommaya reservoir improves survival in leptomeningeal metastasis
- Low pretreatment lymphocyte-to-monocyte ratio linked to worse survival in cervical cancer
- 26 Gy in 5 fractions non-inferior to 40 Gy in 15 fractions for breast cancer recurrence at 10 years
- Mitochondria-targeted strategies show translational potential for improving radiosensitivity in radioresistant tumor cells
- Partial cystectomy in an 80-year-old woman with small cell carcinoma resulted in death after eight months of follow-up
- Local radiopharmaceutical production reduces therapy costs by 93% to 96% across 54 African nations
- Angiogenesis inhibitors combined with chemotherapy improve progression-free survival in advanced breast cancer patients
- Lower baseline quality of life linked to 7% higher mortality risk in lung cancer patients
- Liver transplantation shows improved five-year survival and recurrence outcomes versus resection for combined hepatocellular-cholangiocarcinoma patients in this meta-analysis
- Elevated TRIM47 expression correlates with advanced tumor stage, metastasis, and poor prognosis in cancer
- Exercise-induced myokines show functional duality with tumor-suppressive or tumor-promoting effects depending on microenvironmental context
- Cadmium exposure linked to higher endometrial cancer risk, while PCBs show no association in meta-analysis
- Hodgkin lymphoma survival exceeds 90% in early-stage patients with modern therapy
- Novel strategies aim to separate GVHD from GVL effects in allo-HCT for AML
- Review offers broad scope without specific clinical findings or reported limitations
- Fianlimab plus cemiplimab showed objective response rates of 20% to 33% in advanced solid tumors during a Phase 1 study.
- Lenvatinib plus PD-1 inhibitor improves survival versus bevacizumab plus PD-1 inhibitor in unresectable hepatocellular carcinoma
- Meta-analysis finds modest melanoma risk increase among infertile women using fertility treatments
- Combination immunotherapy and targeted therapy regimens show favorable survival outcomes versus monotherapies in unresectable hepatocellular carcinoma
- Interval-compressed VDC/IE protocol feasibility and outcomes in 27 Ewing's sarcoma patients at a North African center
- Local brain therapies associated with reduced mortality in HNSCC patients with brain metastasis
- Network meta-analysis finds similar overall survival for three HCC regimens
- WBRT shows no significant survival benefit in thyroid cancer brain metastases meta-analysis
- Laparoscopic transabdominal excision of presacral cyst shows no recurrence at 3 months in case report
- TEAS significantly reduces overall PONV risk in patients undergoing breast surgery compared to sham stimulation or routine care
- Information readiness and explicit escalation criteria drive MDT streamlining effects more than caseload reduction
- Volume doubling time under 200 days marks all malignant nodules in 27 studies of lung cancer screening programs
- Statins reduce recurrence risk 23% and mortality in 267,913 HR+ breast cancer patients with HR 0.77
- Giant mesenteric fibromatosis progresses despite targeted therapy and immunotherapy in case report
- IL-17-targeted intervention implications for tissue injury remain uncertain due to lack of holistic regulatory perspective
- cGAS–STING activation correlates with improved survival and enhanced checkpoint blockade response in cancer
- Molecular markers may improve risk assessment in oral potentially malignant disorders
- Vaginal irrigation self-management shows conditional support for cervical cancer patients undergoing radiotherapy
- Systemic cancer treatment linked to 5% skeletal muscle loss over 90 days
- TIL therapy and engineered viral vector immunotherapies show pooled ORR of 37.8% in advanced melanoma
- Digital health tools may ease anxiety and depression in colorectal cancer patients
- Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma shows TTF-1 expression and Ki-67 less than 10% in reported cases
- Nivolumab monotherapy yielded 12-month progression-free survival in metastatic anaplastic thyroid cancer
- T cell-based therapies show promise but face barriers in solid tumors
- Attenuated R-THP-COP regimen achieved complete response in an 85-year-old with diffuse large B-cell lymphoma
- Adding docetaxel to ADT and RT cuts mortality in high-risk prostate cancer with normal testosterone
- Favorable adiposity, statins, vitamin D, dried fruit linked to lower ovarian cancer risk in MR meta-analysis
- Nature-based IVR reduces anxiety and distress in breast cancer patients with low certainty evidence
- FDA Approves Truqap (capivasertib) for HR+/HER2- Advanced Breast Cancer with PIK3CA/AKT1/PTEN Alterations
- FDA Approves Decnupaz for Blastic Plasmacytoid Dendritic Cell Neoplasm
- FDA Approves Imfinzi (durvalumab) for Resectable NSCLC and Other Indications
- FDA Approves Columvi (glofitamab) for Relapsed/Refractory Diffuse Large B-Cell Lymphoma
- FDA Approves Hepzato (melphalan) for Uveal Melanoma with Hepatic Metastases
- VTE risk models in multiple myeloma show low predictive accuracy, pooled AUC below 0.7
- Systematic review shows robotic colorectal surgery lowers CRP and complications versus laparoscopy in adult patients
- Robotic TME reduces CRM positivity and three-year recurrence in mid or low rectal cancer
- Percutaneous thermal ablation shows higher local recurrence than robot-assisted partial nephrectomy for localized renal cell carcinoma
- Immunotherapy improves complete response but lacks overall response benefit in HR+ breast cancer
- Meta-analysis quantifies pre-diagnosis weight loss in pancreatic cancer patients
- Magnifying image-enhanced endoscopy shows high diagnostic accuracy for invasion depth in superficial esophageal neoplasm
- Psychosocial interventions significantly reduce demoralization and depressive symptoms in patients with cancer
- Deep learning models for glioma segmentation achieve high whole tumor accuracy with DSC 0.860
- Regional lymphadenectomy improves survival in resectable gallbladder cancer: meta-analysis
- Extraperitoneal single-port robotic-assisted radical prostatectomy shortens console time by 83 minutes versus multiport transperitoneal approaches in 1997 patients
- Robotic surgery shows shorter operation time and reduced blood loss compared to VATS or open thoracotomy in central NSCLC cases
- Acupuncture, ACT, Nutrition Top Non-Drug Interventions for Lung Cancer
- Particle embolization reduces operative complications compared to liquid agents in meningioma preoperative embolization
- Psychosocial interventions show no significant changes in suicidal behavior severity among cancer patients across nine randomized trials
- Metabolic syndrome linked to higher risk of several obesity-related cancers and worse colorectal cancer survival
- Physical exercise improves cognitive function in patients with cancer, umbrella review finds
- 27648 patients shows robotic TME improves specimen quality and margin safety for rectal cancer cases
- Carer psychological distress linked to worse patient mental health and higher service use in cancer care
- Repeat microsurgery for recurrent vestibular schwannoma achieves gross total resection but increases facial nerve deterioration risk to 43%
- WeChat-based patient-doctor interaction improves patient experience in H. pylori infection treatment
- Weight reduction ranked highest for limb volume, while VR-based training ranked highest for pain in breast cancer-related lymphedema
- Gut microbiome factors and dietary modulation may optimize triple-negative breast cancer management
- FDA Approves Jylamvo (methotrexate) for Multiple Neoplastic and Inflammatory Indications
- Minimally invasive cystectomy reduces blood loss and transfusions but extends operative time
- Adding WBRT to SRS cuts brain metastasis recurrence but raises cognitive decline without survival gain
- Immune checkpoint blockade shows promise but faces resistance challenges in nasopharyngeal carcinoma
- Gastric-type endocervical adenocarcinoma in Peutz-Jeghers syndrome: a case and literature review
- Water infusion during colonoscopy reduces need for sedation and abdominal compression compared to air or CO2 insufflation
- Meta-analysis of CDK4/6 inhibitor rechallenge shows improved progression-free survival in advanced breast cancer
- Narrative review discusses LPA signaling in advanced prostate cancer
- Network meta-analysis ranks nonpharmacological dyspnoea strategies in lung cancer
- Perspective review on radiation therapy and cardiac toxicity in lung cancer
- Scoping review of AI for head and neck cancer risk stratification
- Multicomponent intervention with mailed FIT and navigation increased colorectal cancer screening uptake in Federally Qualified Health Centers
- Review of BsAb-armed T cells for solid tumors and CAR-T and BsAb therapy
- Systematic review and meta-analysis of proximal tibia reconstruction after tumor resection reports complication and survival rates
- Systematic Review: Intercellular Mitochondrial Transfer in Melanoma Progression and Resistance
- FDA Approves Datroway (datroway) for EGFR-Mutated NSCLC and HR+ Breast Cancer
- Systematic review and meta-analysis shows dermoscopy-guided excision reduces incomplete excision in keratinocyte cancer
- Narrative review explores AI-assisted radiotherapy for pelvic and abdominal cancers in Africa
- Systematic review and meta-analysis of TRBC1 flow cytometry for mature T-cell neoplasms
- Systematic review and meta-analysis of n-3 PUFAs for pancreatic cancer patients
- Case report review of acupuncture for chemotherapy-induced peripheral neuropathy in a patient with lung cancer and bone metastasis
- Meta-analysis shows immune checkpoint inhibitor combinations improve survival and response rates in advanced cervical cancer patients with manageable safety profiles
- Review explores host-microbiome interactions in breast cancer
- Systematic review of AI-enhanced oncology MDTs shows mixed concordance and limited cost-effectiveness evidence
- Case report details multimodal treatment for aggressive thyroid carcinoma
- Systematic review shows robot-assisted minimally invasive esophagectomy reduces blood loss and hospital stay compared to conventional minimally invasive approaches for resectable esophageal cancer cases involving adult patients
- Protocol for a systematic review and network meta-analysis of second-line soft tissue sarcoma treatments
- Overweight and obesity linked to increased bladder cancer risk in males in meta-analysis
- Network meta-analysis suggests immune checkpoint inhibitor regimens improve survival in advanced gastric cancer compared to chemotherapy alone
- Systematic review and meta-analysis on pre-diagnostic weight loss in pancreatic cancer
- Review of Non-small cell lung cancer without reported intervention or outcomes
- Narrative review discusses SECTM1 for cancer, cardiovascular disorders, and neurodegenerative diseases without reported outcomes or safety data
- Healthcare professionals need updated guidance on managing breast cancer-related lymphedema effectively today
- Narrative review discusses CMTM4 role in cancer tumor immune microenvironment with noted translational challenges
- Meta-analysis links high platelet ratios to worse overall survival in adult glioblastoma patients
- Meta-analysis finds robotic low anterior resection improves outcomes in younger rectal cancer patients
- Palliative care consultation for bone metastases radiotherapy patients shows no outcome data in protocol
- FDA Approves Herceptin (trastuzumab) for HER2-Overexpressing Breast and Gastric Cancers
- FDA Approves Phesgo (pertuzumab, trastuzumab, hyaluronidase) for HER2-Positive Breast Cancer
- FDA Approves Herceptin Hylecta (trastuzumab/hyaluronidase) for HER2+ Breast Cancer
- PD-1/PD-L1 inhibitors improve response in dMMR/MSI-H metastatic colorectal cancer
- Fulvestrant maintenance improves PFS versus capecitabine in HR+ HER2- metastatic breast cancer
- Systematic review and meta-analysis on neoadjuvant chemoimmunotherapy for resectable NSCLC
- Case report on VMAT radiotherapy for inoperable anal Buschke-Lowenstein tumors
- Review of AI models shows high accuracy for ovarian cancer diagnosis and outcome prediction
- Systematic review and meta-analysis links benzene exposure to increased lymphoid neoplasm risk
- Unplanned Healthcare Encounters Common in Pediatric Cancer
- Systematic Review Maps Exponential Growth of Antibody-Drug Conjugate Trials in Lung Cancer
- Meta-analysis links emotional distress to worse outcomes in advanced lung cancer
- Systematic review and meta-analysis links higher prognostic nutritional index to better survival in non-small cell lung cancer
- Meta-analysis shows bevacizumab plus FOLFOX improves response rates without increasing common toxicities in advanced colorectal cancer
- Systematic review and meta-analysis of DDS-based chemotherapy in murine colon cancer models
- Network meta-analysis compares therapies for liver metastatic uveal melanoma
- Postoperative VTE prediction models show substantial heterogeneity and high bias risk in lung cancer surgery patients undergoing systematic review analysis
- Systematic review of immune checkpoint inhibitors in cancer efficacy and safety
- Narrative review discusses AI-driven pathology models for esophageal cancer and Barrett's esophagus management
- Evidence mapping review on nutritional prehabilitation for head and neck cancer patients
- Tucidinostat plus R-CHOP improves outcomes in MYC/BCL2 double-expressor DLBCL
- Mind-body therapies reduce depression and anxiety in people with cancer, network meta-analysis finds
- Meta-analysis shows PET/CT alters management in one of five adults with abdominal malignancies
- Meta-analysis finds survivorship programs improve quality of life in colorectal cancer survivors
- Review of a case report on epithelioid clear cell mesothelioma in a 76-year-old male with 24 months follow-up
- Systematic review and meta-analysis links infertility to higher thyroid cancer risk
- Robotic low anterior resection for rectal cancer shows lower conversion and mortality vs laparoscopic approach
- Systematic review and meta-analysis of remote-access thyroidectomy versus open thyroidectomy in thyroid cancer patients
- Yoga reduces depression in breast cancer patients across multiple treatment groups
- Systematic review and meta-analysis finds higher intracranial aneurysm prevalence in pituitary adenoma patients
- Systematic review and meta-analysis on neoadjuvant selection and liver transplantation for perihilar cholangiocarcinoma
- Narrative review explores macrophage reprogramming for liver fibrosis and MASH
- Case review of epithelial-type Wilms tumor in a 23-year-old female with clear surgical margins
- Systematic Review Links Neural Circuit Disturbances to Glioma Symptoms and Survival
- Age and comorbidity do not raise severe complication risk after minimally invasive esophagectomy
- Review of gynecologic malignancies highlights dormant tumor cells as a therapeutic target
- Systematic review finds activity pacing may improve cancer-related fatigue during chemotherapy
- Closing rectal wall defects after full-thickness excision reduces bleeding and re-admission rates compared to leaving defects open in patients with rectal neoplasms
- Ibrutinib plus chemo without ASCT shows survival benefit in mantle cell lymphoma
- Angiogenic ccRCC tumors show higher pancreatic metastasis rate in phase II trial
- FDA Approves Ziextenzo (pegfilgrastim-bmez) for Febrile Neutropenia and Acute Radiation Syndrome
- FDA Approves Abiraterone Acetate (Yonsa) for Metastatic Castration-Resistant Prostate Cancer
- Morning immune checkpoint inhibitor infusions associated with improved survival in metastatic non-small-cell lung cancer
- Narrative review of adoptive cell therapies for solid tumors and their challenges
- Narrative review on emergency colorectal cancer management in patients aged 80 years and older
- Review of glioma organoid models for mechanistic discovery and therapy development
- Meta-analysis of PET/CT metabolic parameters for predicting NSCLC response after neoadjuvant therapy
- Systematic review and meta-analysis on immunotherapy for head and neck squamous cell carcinoma
- PSA-based prostate cancer screening reduces mortality but increases diagnoses
- FDA approves OPDIVO QVANTIG for multiple advanced cancer indications including renal cell carcinoma and melanoma
- FDA Approves Tecentriq Hybreza (atezolizumab/hyaluronidase) for Multiple Cancers
- FDA Approves Tecentriq (atezolizumab) for Alveolar Soft Part Sarcoma
- Robot-assisted distal pancreatectomy reduces blood loss and conversions but increases operative time and cost
- Prolonged time-to-surgery after chemoradiotherapy improves preoperative quality of life in esophageal cancer
- Postoperative exercise interventions shorten intestinal recovery time in colorectal cancer surgery