Senolytic clearance and epigenetic remodeling offer a proposed roadmap to treat intervertebral disc degeneration
New strategies target aging cells to treat spinal disc decay
This systematic review examines the role of cellular senescence and epigenetic dysregulation in intervertebral disc degeneration (IDD). The …
Scientists have identified a way to stop the cycle of cell aging that causes spinal discs to break down and lose their function.
Regulatory suspension prohibits DCLVA use for Alzheimer's disease due to unresolved physiological uncertainties and scientific gaps
Regulatory suspension blocks use of DCLVA for Alzheimer's disease
This narrative review examines the potential of deep cervical lymphaticovenous anastomosis (DCLVA) for patients with Alzheimer's disease. Th…
A regulatory suspension currently prohibits using Deep cervical lymphaticovenous anastomosis for Alzheimer's disease because major scientifi…
Physical exercise therapy may support osteosarcopenia management in elderly patients according to this narrative review
Exercise may help fight bone and muscle loss in aging
This narrative review discusses physical exercise therapy for osteosarcopenia in the elderly population. The authors outline potential benef…
A new review suggests physical exercise could slow bone and muscle loss in older adults with osteosarcopenia.
Meta-analysis finds no significant association between statin use and sarcopenia in older adults
Large review finds no clear link between statin use and muscle loss in older adults
A systematic review and meta-analysis of 9,080 older adults from European and Asian populations found no statistically significant associati…
A large review of over 9,000 older adults found no clear link between taking statins and losing muscle mass or strength.
Histone lactylation and glycation drive aging; NAD+ restoration and carbonyl stress reduction show promise
Histone modifications reveal new targets for slowing aging
This mini review synthesizes evidence on histone acetylation, lactylation, and glycation in aging. It highlights crosstalk among these modif…
A new review shows how histone changes like lactylation and glycation drive aging, pointing to NAD+ and stress reduction as key intervention…
Exercise intensity and type shape affective responses in older adults, review finds
Exercise research reveals hidden mood differences in older adults
This theoretical review examines how exercise intensity, type, duration, and frequency influence affective valence and arousal in older adul…
New analysis shows how exercise impacts older adults differently than we thought, but current mood measures might be hiding important detail…
Metabolic and bariatric surgery yields significant body weight variations in sarcopenic obesity versus non-sarcopenic obesity
Metabolic surgery helps people with sarcopenic obesity lose weight and improve health
This systematic review and meta-analysis evaluated metabolic and bariatric surgery (MBS) outcomes in a global sarcopenic obesity population …
A global review of 1,704 patients shows metabolic surgery helps those with sarcopenic obesity lose weight and manage health issues better th…
Combined aerobic and resistance training significantly improves FEV1, FVC, and MIP in older sarcopenic patients
Combined exercise training improves lung function in older adults with muscle loss
This systematic review and meta-analysis of 655 older patients with sarcopenia found that combined aerobic and resistance training significa…
Older adults with muscle loss gain better lung function when doing both aerobic and resistance training together, not just one type.
Gut microbes and metabolites may influence aging, though human evidence remains limited
Gut microbes may influence aging, but human evidence remains limited
This narrative review examines the role of gut microbes and their metabolites in aging. The authors note that most evidence comes from anima…
A review suggests gut microbes might affect aging, yet most data comes from animals and direct human proof is still missing.
Whey protein, vitamin D, and epicatechin show strongest effects on sarcopenia outcomes in network meta-analysis
Whey protein and Vitamin D help older adults with muscle loss
This systematic review and network meta-analysis of anti-inflammatory diets and supplements in elderly patients with sarcopenia found whey p…
A large review found that whey protein, Vitamin D, and specific supplements can improve strength and speed in older adults with muscle loss.
PromeTheus programme improves function and frailty in frail older adults versus usual care
Home exercise helps frail older adults improve function and reduce frailty
This randomized controlled trial enrolled 385 community-dwelling (pre)frail older adults aged 70 years or older with a clinical frailty scal…
A home-based exercise program improved physical function and frailty in frail older adults, though it did not reduce falls or improve life-s…
Risk factors for sarcopenic obesity in older adults include age, physical inactivity, diabetes, and hypertension
Older Adults With Low Muscle Mass And Fat Face Many Health Risks
This meta-analysis review examined risk factors for sarcopenic obesity in a population of 90,786 older adults. The analysis identified demog…
A large review found many things that increase the chance of sarcopenic obesity in seniors. Age, lack of exercise, and certain health proble…
All Geriatrics & Aging Articles
- Senolytic clearance and epigenetic remodeling offer a proposed roadmap to treat intervertebral disc degeneration
- Regulatory suspension prohibits DCLVA use for Alzheimer's disease due to unresolved physiological uncertainties and scientific gaps
- Physical exercise therapy may support osteosarcopenia management in elderly patients according to this narrative review
- Meta-analysis finds no significant association between statin use and sarcopenia in older adults
- Exercise intensity and type shape affective responses in older adults, review finds
- Histone lactylation and glycation drive aging; NAD+ restoration and carbonyl stress reduction show promise
- Risk factors for sarcopenic obesity in older adults include age, physical inactivity, diabetes, and hypertension
- Metabolic and bariatric surgery yields significant body weight variations in sarcopenic obesity versus non-sarcopenic obesity
- PromeTheus programme improves function and frailty in frail older adults versus usual care
- Gut microbes and metabolites may influence aging, though human evidence remains limited
- Integrated care improves frailty and functional ability in community-dwelling frail older adults but lacks consistent benefits for other outcomes
- Whey protein, vitamin D, and epicatechin show strongest effects on sarcopenia outcomes in network meta-analysis
- Combined aerobic and resistance training significantly improves FEV1, FVC, and MIP in older sarcopenic patients
- Narrative review explores gut microbiota role in postoperative delirium in liver disease
- Mini review argues immunosenescence framework may unify frailty and multimorbidity in later life
- Review of senescence-associated secretory phenotype in aging osteoarthritis and disc degeneration
- Systematic review of AI for schizophrenia prediction using medical imaging data
- Narrative review identifies five dimensions influencing mental health care access for youth with disabilities
- Mini review synthesizes PQQ and spermidine roles in healthy longevity mechanisms
- Systematic review of machine learning models for fall prediction in community-dwelling older adults shows high bias
- Telemedicine-based STEADI implementation showed no difference in self-reported falls among older adults compared to standard care
- Meta-analysis of digital health interventions for frailty and sarcopenia in older adults
- Scoping review finds limited use of ICF capacity and performance qualifiers in clinician assessments
- Systematic review and meta-analysis of multisensory integration training in healthy older adults shows improved balance and reduced fall risk
- Systematic review and meta-analysis on deprescribing psychotropics to reduce falls in older adults
- MIRA feasibility study in Dutch long-term care organizations shows good reliability and high acceptability among professionals
- Systematic review validates eDEM-CONNECTONTO ontology for dementia caregiver support tools
- Hybrid NLP and LLM system extracts deprescribing recommendations from electronic health records for older hospitalized patients
- Acupuncture combined with Baduanjin improves muscle mass and function in older adults with sarcopenia
- Systematic review and meta-analysis of digital-based exercise interventions for older adults
- Pilot study assesses safety and feasibility of young donor plasma replacement in mild cognitive impairment
- Early-Onset Colorectal Cancer Shows Superior Survival vs Late-Onset in Retrospective Cohort
- Living alone not linked to incident dementia but associated with higher institutionalization risk in a cohort of 2,269 individuals
- Undifferentiated Pleomorphic Sarcoma Recurrence Observed two months Postoperatively in Case Report of Gastric Mass
- Cross-sectional study observes differences in cardiovascular regulatory responses in mild cognitive impairment
- DISCO metric from proteomics predicts mortality and frailty in older adults
- Prediabetes Associated With Higher Incidence of Frailty and Functional Deficits in Adults Aged 50 Years or Older
- Machine learning analysis identifies drivers of medication burden in older Nepalese patients
- Infection status associated with hypoxemia and death rates varying by virus type in a large US cohort
- Personalized swallowing rehab improves outcomes after oral cancer surgery
- Narrative review on mpMRI and PSMA PET/CT for radiorecurrent prostate cancer restaging
- AI-assisted Bayesian framework identifies Alzheimer's gene pathways in single-cell RNA data
- Mixed-methods review evaluates usability of iSupport-Malaysia for dementia caregivers in Malaysia
- Genome-wide association study identifies inverse association between HSV-1 DNA and Alzheimer's disease risk
- Nocturnal sensor signals may predict next-day agitation in dementia cohorts
- Chinese BERNCA-NH shows acceptable preliminary psychometrics in 251 nursing assistants
- AD8 Dementia Screening Items Show Associations with Functional and Psychosocial Outcomes in Chinese Older Adults
- Pilot RCT in veterans with depression finds no benefit from immediate PGx testing
- Adapted-dose FOLFIRINOX assessed for safety and early efficacy in elderly patients with metastatic pancreatic cancer
- Physical activity interventions may improve function in temporarily non-ambulant older persons
- Systematic review of osteoporosis interventions reports mixed outcomes with no specific medication data provided
- Phenolic-rich olive oil with prebiotics may improve muscle measures in older adults with sarcopenia
- PCKP reduces early pain and leakage versus UPKP in osteoporotic vertebral fractures
- Resting-state facial expressions differ significantly between older adults with mild cognitive impairment and healthy controls
- Dementia prevention class shows no effect on dementia onset or insurance certification in observational study
- Multifactorial interventions and exercise programs showed mixed effects on falls and fractures in older adults
- Group dance interventions improved physical performance and cognition in community-dwelling older adults with sarcopenia
- Risk model based on lifestyle factors shows discriminative ability for colon cancer and precancerous lesions
- Perioperative multicomponent exercise rehabilitation reduces postoperative complications in frail elderly patients undergoing surgery
- Biological age acceleration linked to faster progression from cardiovascular-kidney-metabolic disease to dementia
- Cross-sectional study finds age-related fatty acid profile differences in metabolic clinic patients
- Cross-sectional study links CKD, sarcopenia, and undernutrition to CVD history in older Japanese adults
- Multimodal sensor-based framework detects frailty in retired adults aged 65+ in primary care
- Systematic review finds limited evidence for antibiotics in low back pain with Modic changes
- Home-based cardiac rehabilitation improved physical function in frail older patients with cardiovascular disease
- First-year medical students show increased BMI and stress, decreased motivation during academic year
- Stroke survivors face substantially increased hip fracture incidence and elevated mortality compared to non-stroke populations
- Exercise training improves multiple outcomes in frail older adults with heart failure
- Advance care planning documentation associated with lower life-sustaining treatment and higher hospice enrollment in older US adults
- Systematic review examines nine therapeutic peptides for targeting aging hallmarks in older adults
- Review summarizes Aβ-targeted Alzheimer's vaccine progress from failed first-generation to promising next-generation candidates
- Otago Exercise Program improves knee function and mobility after total knee arthroplasty in meta-analysis
- HIIT reduces sarcopenia risk and preserves grip strength in older adults over 5-year RCT
- Face-to-Face Training Shows Greater Short-Term Gains Than Remote in Fall Prevention Program for Older Adults
- Exercise reduces complications and improves function in frail elderly cancer patients on chemotherapy
- Sleep Problems Associated With Impaired Gait Quality and Higher Fall Risk in Older Adults
- Older adults with fewer than 20 teeth have 3.6 times higher odds of frailty in meta-analysis
- Systematic review finds wide variation in neurodegenerative disease prevalence among older Russian adults
- 24-week self-determined sequence exercise program shows significant interactions for sarcopenia reversal in older adults
- History of falls is associated with increased risk of future dementia in adults aged 40 years and older
- Exercise training improves physical performance and handgrip strength in frail nursing home residents
- Observational study links frailty index and neuroimaging markers to dementia risk in UK Biobank cohort
- Whole-body vibration with blood flow restriction training may improve sarcopenia measures in older adults
- Qualitative study identifies systemic barriers and caregiver burden in Latino dementia care navigation
- Discordant multimorbidity linked to poorer health status and higher healthcare use in Chinese adults
- In Silico Platform Shows Promise for Creating Personality-Stable Elderly Digital Twin Agents
- Phase 3 trial of TMB-001 topical ointment for congenital ichthyosis reports no efficacy results
- Scoping review identifies 19 factors influencing caregiver support for older adults in rural areas
- Systematic review finds predictive models for dysphagia risk in older adults show variable performance
- CBD oil shows no surrogate evidence of drug interactions with opioids or benzodiazepines in advanced cancer patients
- Qualitative study identifies themes influencing adherence to foot strengthening in older adults
- Sarcopenic obesity prevalence is 28% in adults with advanced knee OA and severe obesity
- Interprofessional medication review shows non-significant improvement in prescribing appropriateness for older ED patients
- Exergaming improves strength and balance versus conventional therapy in healthy older adults