Semaglutide reduces insulin dose in adults with type 1 diabetes and obesity
Semaglutide Cuts Insulin Needs By Half In Type 1 Diabetes
A post hoc analysis of an RCT found that semaglutide 1 mg/week significantly reduced total daily insulin dose by 22.6% over 26 weeks in adul…
Semaglutide reduces insulin needs quickly in type 1 diabetes patients, offering a new hope for better blood sugar control and weight managem…
Semaglutide improves physical quality of life in schizophrenia with prediabetes
Semaglutide improves physical quality of life in adults with schizophrenia and obesity
This secondary analysis of a randomized trial in 154 adults with schizophrenia, prediabetes, and overweight or obesity found that once-weekl…
A secondary analysis of a trial found that once-weekly semaglutide improved physical quality of life in adults with schizophrenia and obesit…
Adjunctive JNJ-42165279 fails to improve depression in SSRI/SNRI inadequate responders
Early trial finds new drug did not help depression in patients already on antidepressants
This phase 2a double-blind RCT tested adjunctive JNJ-42165279 25 mg daily versus placebo in 153 adults with major depressive disorder with a…
A small early study found a new drug did not improve depression symptoms for patients already taking standard antidepressants.
Chiglitazar reduces liver fat in MASLD patients with hypertriglyceridemia and insulin resistance
Two doses of chiglitazar cut liver fat far more than a placebo in 18 weeks
In a phase II randomized, double-blind, placebo-controlled trial, 104 patients with MASLD, hypertriglyceridemia, and insulin resistance rece…
Patients with fatty liver disease and high triglycerides saw liver fat drop significantly with chiglitazar compared to placebo after 18 week…
Oral Sodium Butyrate Reduces Weight in Overweight Adults Without Diabetes
Oral sodium butyrate helps overweight adults without diabetes lose weight
This 12-week proof-of-concept RCT in 46 overweight adults (23 with type 2 diabetes) found that oral sodium butyrate 1875 mg/day led to great…
A new trial shows oral sodium butyrate helps adults without diabetes lose more weight than a placebo over three months.
Glenzocimab fails to improve outcomes in acute ischemic stroke thrombolysis
New stroke drug shows no benefit for patients treated with clot-busting therapy
This phase 2/3 randomized trial tested glenzocimab versus placebo in 421 patients with acute ischemic stroke treated by thrombolysis.
A major trial found that glenzocimab did not improve long-term disability scores for stroke patients who received standard clot-busting trea…
Romosozumab improves shear bone strength in postmenopausal women with osteoporosis in BCT substudies
Romosozumab May Help Spinal Fusion Surgery Last Longer
This retrospective secondary analysis of phase 2 and 3 randomized trial data evaluated romosozumab in postmenopausal women with low bone den…
A bone drug may make spinal fusion surgery more secure for women with weak bones, new virtual tests suggest.
Plozasiran reduces recurrent pancreatitis in familial chylomicronaemia syndrome post hoc analysis
New drug slashes pancreatitis attacks in high-risk patients
This post hoc analysis of a Phase 3 RCT in 67 adults with very severe hypertriglyceridemia and pancreatitis history found that subcutaneous …
A new treatment cuts pancreatitis flare-ups in people with dangerously high blood fats, offering hope for those with few options and constan…
Dry NaCl Inhalation Fails to Improve Mucociliary Clearance in COPD
Inhaled salt fails to clear mucus in COPD trial
This randomized, placebo-controlled crossover study in 25 patients with GOLD stage I-III COPD found that a single 40 mg dry NaCl inhalation …
Inhaling dry salt did not improve mucus clearance in COPD patients, a small trial finds. The study was cut short by COVID-19.
Essential phospholipids reduced hepatic steatosis and improved HbA1c in patients with MASLD and type 2 diabetes over 6 months
Essential Phospholipids Reduce Liver Fat In Six Months
This randomised, placebo-controlled phase 4 trial enrolled 193 patients with metabolic dysfunction-associated steatotic liver disease and ty…
Essential phospholipids may lower liver fat and improve energy levels for people with fatty liver disease and diabetes within just six month…
Memantine improved neuropathy severity and pain scores versus placebo in CIPN over eight weeks
Memantine eased nerve pain and tingling for chemotherapy patients in eight weeks
This randomized clinical trial enrolled 176 individuals with chemotherapy-induced peripheral neuropathy.
A new trial found memantine significantly reduced nerve pain and tingling in chemotherapy patients compared to placebo over eight weeks.
Semaglutide high dose for weight reduction in people with Type 2 Diabetes
New drug helps obese diabetics lose weight and control sugar
This randomized controlled trial in 512 people with excess weight and Type 2 Diabetes compared high-dose semaglutide to placebo and lower do…
New research shows a specific injection helps people with obesity and diabetes lose weight and control their blood sugar levels better than …