JAK inhibitors are associated with higher hepatitis B virus reactivation rates than IL-12/23 or IL-17 inhibitors
Specific Immune Inhibitors Show Varying Risks for Hepatitis B Reactivation
This meta-analysis of 29 studies evaluated the risk of hepatitis B virus reactivation (HBVr) in patients receiving various immunomodulators.…
New analysis shows that certain immune inhibitors like JAK inhibitors may carry a higher risk of hepatitis B reactivation than other drug cl…
Immune crosstalk between innate and adaptive compartments drives inflammatory mechanisms in MASLD and MASH progression
Immune system crosstalk drives fatty liver disease progression
This systematic review examines the role of immune system interactions in metabolic dysfunction-associated steatotic liver disease (MASLD) a…
A new review reveals that immune cells talking to each other may be what pushes fatty liver disease toward severe liver damage.
Schroth combined with sensory integration training shows greatest Cobb angle reduction in adolescent idiopathic scoliosis
Specific exercise routines may help reduce scoliosis curvature in teens
This network meta-analysis of 1,149 patients evaluated various scoliosis-specific exercise protocols for adolescent idiopathic scoliosis. Th…
A specific combination of Schroth exercises and sensory training shows promise in reducing spinal curvature for teens with idiopathic scolio…
Plant-derived exosome-like nanoparticles mitigate weight loss and improve colon length in ulcerative colitis models
Plant Nanoparticles Show Potential to Treat Ulcerative Colitis
This meta-analysis of 25 preclinical studies involving 304 animal subjects indicates that plant-derived exosome-like nanoparticles (PELNs) m…
New research on plant-derived nanoparticles shows promise for treating ulcerative colitis symptoms and improving gut health in animal models…
Axial psoriatic arthritis is associated with significantly lower HLA-B27 positivity than axial spondyloarthritis
Genetic Markers Help Distinguish Psoriatic Arthritis From Spondylitis
This meta-analysis compared clinical features between patients with axial psoriatic arthritis (ax-PsA) and axial spondyloarthritis (ax-SpA).…
A large review of over 10,000 patients shows that specific genetic markers can help doctors tell two similar types of arthritis apart.
The bile acid-gut microbiota-vitamin D axis may influence pathogenesis of biliary atresia
Bile acid-gut microbiota-vitamin D axis may affect biliary atresia
This systematic review examines the roles of bile acid metabolism, gut microbiota composition, and vitamin D levels in children with biliary…
A new review suggests a link between bile acids, gut bacteria, and vitamin D in biliary atresia, offering potential new treatment targets.
Oral diseases stem from disrupted host-microbiome-immune balance, narrative review argues
New research explores how oral bacteria drive gum disease
This narrative review argues that periodontitis, dental caries, and oral squamous cell carcinoma should be understood as disorders of host-m…
Oral health depends on a delicate balance between your immune system, tissue barriers, and the trillions of microbes living in your mouth.
Anthraquinone laxatives may produce active metabolites via gut microbiota conversion leading to melanosis coli
Gut bacteria may turn laxatives into active compounds for some
This narrative review examines the role of gut microbiota and anthraquinone biotransformation in the development of melanosis coli. The auth…
Your gut bacteria might be changing how your body processes certain laxatives, potentially contributing to a condition called melanosis coli…
Long COVID causes consistent long-term deterioration in physical functioning, vitality, fatigue, and respiratory distress
Long COVID causes lasting decline in physical function and vitality
This systematic review of 10 studies involving 1,078 patients with Long COVID identifies a consistent decline in health-related quality of l…
People with Long COVID face significant long-term struggles with fatigue, pain, and daily activities compared to healthy individuals.
Lower liver-expressed TRIB1AL levels are associated with reduced liver fat and cardiovascular risk
Genetic research identifies a new target for fatty liver disease
This meta-analysis examines the role of long noncoding RNA TRIB1AL in metabolic dysfunction-associated steatotic liver disease (MASLD). The …
Researchers identified a specific gene, TRIB1AL, that could be a key target for treating fatty liver and heart health issues.
Astragalus membranaceus derivatives restore immune tolerance and homeostasis in digestive system diseases
Astragalus herb shows promise for digestive diseases
This systematic review of 112 studies examines the immunomodulatory mechanisms of Astragalus membranaceus and its derivatives. The authors c…
A review of 112 studies finds Astragalus membranaceus may help restore immune balance in digestive diseases.
Laparoscopic partial hepatectomy provides definitive diagnosis and treatment for large atypical hepatic lesions in adolescents
Surgery provides clear diagnosis for large liver growths in teens
This case report and literature review describes a 17-year-old female with an enlarging focal nodular hyperplasia (FNH) lesion. The authors …
A growing liver mass in a teenager was finally identified as a specific type of growth after surgery provided a definitive diagnosis.
All Gastroenterology Articles
- JAK inhibitors are associated with higher hepatitis B virus reactivation rates than IL-12/23 or IL-17 inhibitors
- Immune crosstalk between innate and adaptive compartments drives inflammatory mechanisms in MASLD and MASH progression
- Schroth combined with sensory integration training shows greatest Cobb angle reduction in adolescent idiopathic scoliosis
- Plant-derived exosome-like nanoparticles mitigate weight loss and improve colon length in ulcerative colitis models
- The bile acid-gut microbiota-vitamin D axis may influence pathogenesis of biliary atresia
- Axial psoriatic arthritis is associated with significantly lower HLA-B27 positivity than axial spondyloarthritis
- Oral diseases stem from disrupted host-microbiome-immune balance, narrative review argues
- Anthraquinone laxatives may produce active metabolites via gut microbiota conversion leading to melanosis coli
- Long COVID causes consistent long-term deterioration in physical functioning, vitality, fatigue, and respiratory distress
- Astragalus membranaceus derivatives restore immune tolerance and homeostasis in digestive system diseases
- Laparoscopic partial hepatectomy provides definitive diagnosis and treatment for large atypical hepatic lesions in adolescents
- Lower liver-expressed TRIB1AL levels are associated with reduced liver fat and cardiovascular risk
- Infliximab may offer clinical improvement and wound reduction in non-Crohn's disease related fistulas
- Acupuncture modulates the microbiota-gut-brain axis to remodel microbial structure in patients with irritable bowel syndrome
- Reduced Shannon index indicates lower alpha-diversity in the gut microbiota of patients with primary biliary cholangitis
- Probiotic supplementation may improve salivary buffering and reduce cariogenic bacteria
- Balloon-assisted ESD shows comparable outcomes to conventional ESD for colorectal polyps
- Sympathovagal imbalance correlates with IBS symptom severity and shows subtype specificity
- Narrative review offers a theoretical framework for personalized management of acute upper gastrointestinal bleeding in patients
- Adding linaclotide to PEG did not improve bowel prep quality in high-risk colonoscopy patients undergoing screening procedures
- CYP7A1 and SLC39A9 variants linked to bile acid levels and cholestasis in Chinese women
- Gut-liver axis models evolve from static co-cultures to microfluidic systems, review finds
- Macrophage targeting offers new theoretical approaches for treating gastrointestinal motility disorders and constipation
- Dynamic LSM changes predict liver events in advanced chronic liver disease
- Gut microbiota alterations linked to anxiety and depression in inflammatory bowel disease patients
- Large meta-analysis identifies 30 new genetic loci for ankylosing spondylitis risk
- Oxaliplatin addition to rectal cancer chemoradiation improves tumor regression
- PFIC null genotype linked to 2.79-fold higher odds of liver transplantation
- Hepatologist-led palliative care matches specialist care for cirrhosis and cancer patients
- Fecal DNA testing improved colorectal cancer screening rates compared to immunochemical testing in primary care
- 1 in 6 dromedary camels in Africa carries Rift Valley Fever antibodies
- General obesity, central obesity, and high triglycerides increase risk of precancerous polyps in colorectal cancer surveillance
- Combining Pentraxin-3 and AFP increases sensitivity to 0.92 for hepatocellular carcinoma diagnosis in chronic liver disease
- Endovascular interventions reduce rebleeding risk versus endoscopic cyanoacrylate injection in gastric variceal hemorrhage
- Antimicrobial resistance reaches 33.3% in cirrhosis patients with bacterial infections across global settings
- Prophylactic clipping after colorectal ESD reduces delayed bleeding risk by 74%
- FIPS AUC 0.821 outperforms MELD scores for 90-day mortality prediction in TIPS for ascites
- Blood-based ctDNA tests show low sensitivity for advanced colorectal neoplasia in asymptomatic adults
- Chemoimmunotherapy improves survival in solid tumors regardless of liver metastasis status
- Persistent ymrEMVI and ymrTD on post-neoadjuvant MRI predict inferior disease-free and overall survival in rectal cancer patients
- Higher TyG Index Linked to 4.36-Fold Increased Odds of NAFLD in Large Meta-Analysis
- Microbiome and metabolite markers may enhance colorectal cancer detection and therapeutic guidance strategies
- GLP-1 receptor agonists show potential benefits for metabolic dysfunction-associated steatotic liver disease with acceptable safety
- IL-1β inhibition may alleviate aortic aneurysm immunopathology, review suggests
- Narrative review links gut microbial metabolites to colorectal cancer mechanisms
- FDA Approves Linzess (linaclotide) for IBS-C, CIC, and Pediatric Functional Constipation
- Narrative review links hidradenitis suppurativa to metabolic dysfunction and systemic inflammation
- Bayesian network meta-analysis of drugs for pediatric NAFLD steatosis improvement
- FDA Approves Cholbam (cholic acid) for Bile Acid Synthesis Disorders and Peroxisomal Disorders
- Narrative review explores microbiome-targeting therapies for inflammatory bowel disease patients
- Ursodeoxycholic acid reduces ALT and fibrosis in chronic liver disease patients
- Review of chemopreventive strategies for familial adenomatous polyposis including NSAIDs and other agents
- Review of dietary patterns and probiotics in swine production provides theoretical basis for microbiome interventions
- Pediatric Gut Microbiome Links to Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
- Systematic review shows high fatigue and pruritus prevalence in primary biliary cholangitis patients
- Meta-analysis shows curcumin reduces weight but lacks impact on BMI or waist circumference in metabolic fatty liver disease patients
- Systematic Review Explores Ubiquitination in Bacterial Infection and Immune Response
- Review of sphincter-preserving techniques for ultra-low rectal cancer
- Network meta-analysis of phase 2-3 therapies for non-cirrhotic metabolic dysfunction-associated steatohepatitis
- Narrative review explores plant-derived extracellular vesicles for rheumatoid arthritis
- Chinese Version of IBS-SSS Validated for Outcome Assessment in IBS Patients
- Critical review links ADMA levels to endothelial impairment in pregnant women with HIV and preeclampsia in sub-Saharan Africa
- Integrative review links chronic heavy metal exposure to intestinal infection susceptibility in Yunnan
- Meta-analysis of perioperative probiotics shows non-significant reduction in postoperative infections for GI surgery patients
- Systematic review and meta-analysis shows worse liver transplant survival for Black patients compared to White patients
- Review of gut microbiota and colorectal cancer highlights unresolved causality and clinical translation challenges
- Systematic review links gut microbial metabolites to colitis-associated colorectal cancer risk
- High CALLY index predicts improved survival outcomes in colorectal cancer patients compared to low scores
- Metabolic dysfunction-associated steatotic liver disease patients with advanced fibrosis face high hepatocellular carcinoma risk over ten years
- Endoscopic submucosal dissection outperforms precut mucosal resection for colorectal polyp removal
- Surgical resection shows superior survival outcomes compared to radiofrequency ablation for small hepatocellular carcinoma cases
- Bismuth quadruple therapy shows higher H. pylori eradication in pediatric patients with clarithromycin resistance
- Early magnesium sulphate catharsis reduces severe acute pancreatitis and mortality in high-risk patients
- Sequential SBRT, pembrolizumab, and resection in oligometastatic colorectal cancer shows 60% 1-year RFS
- Narrative review discusses NF-kB inhibition for inflammatory bowel diseases and related conditions
- Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
- Single 6 mg erdafitinib dose shows similar pharmacokinetics in mild or moderate hepatic impairment versus healthy controls
- Five ACLF diagnostic models and prognostic scores identified markedly different proportions of patients at risk of 28-day mortality in a cohort study
- SABR shows worse survival in ultracentral pulmonary oligometastases compared to nonultracentral tumors
- SABR in oligometastatic cancer showed median overall survival of 64.6 months in a single-arm phase 2 study
- Tislelizumab plus chemotherapy and radiotherapy yields 89.1% 3-year disease-free survival in pMMR/MSS locally advanced rectal cancer
- Patient Buddy App reduced avoidable readmissions in cirrhosis inpatients compared to standard of care
- Chiglitazar reduces liver fat in MASLD patients with hypertriglyceridemia and insulin resistance
- Text reminders and letters increased FIT completion in overdue colorectal cancer screening patients
- AI-Assisted Colonoscopy Improves Right-Sided Adenoma Detection in Gastroenterology Fellows
- Zibotentan plus dapagliflozin shows no HVPG reduction in compensated cirrhosis
- Avelumab plus cetuximab versus cetuximab alone in metastatic colorectal cancer patients
- Preoperative symbiotic supplementation alters gut microbiota in colorectal cancer patients
- HEV 239 vaccine induces durable humoral and cellular immunity in Bangladeshi women
- TaTME shows lower conversion rates with similar short-term safety compared to LapTME for low rectal cancer
- Systematic review and meta-analysis evaluates ML and DL models for diagnosing MASH and fibrosis
- Meta-analysis of placebo responses in metabolic dysfunction-associated steatohepatitis trials reveals modest natural resolution rates and low progression risk
- Meta-analysis finds Virtual Scale Endoscopy improves colorectal polyp measurement accuracy
- Systematic review and meta-analysis of colorectal cancer screening prevalence in survivors versus general population
- Meta-analysis finds R1 vascular margin acceptable for HCC but not CLM in minimally invasive liver surgery
- Educational programs improve self-care values in ostomized colorectal cancer patients
- Systematic review and meta-analysis assesses SWDS diagnostic accuracy for MASLD liver inflammation grading
- Systematic review finds weak link between atypical antipsychotics and MASLD in youth
- Meta-analysis finds blood biomarkers predict outcomes in anal cancer but need validation
- Systematic review shows high rates of fibrosis and cirrhosis in children with Pi*ZZ alpha-1 antitrypsin deficiency
- PPAR Agonists Reduce Pruritus in PBC: Meta-Analysis of 660 Patients
- Systematic review and meta-analysis of biopsy-guided versus clinically guided withdrawal in autoimmune hepatitis
- Narrative review of traditional Chinese medicine for pancreatitis management
- Retrospective review suggests preoperative data predicts skeletal muscle loss in gastric cancer patients
- Probiotic co-administration with berotralstat improves GI tolerability in HAE patients
- Multi-omics profiling identifies molecular associations in recurrent pregnancy loss
- Narrative review of oxidative stress and antioxidant defense in periodontitis and peri-implantitis
- Meta-analysis shows reduced oral microbial Shannon diversity in Crohn's disease versus controls
- Narrative review examines links between periodontitis and systemic disorders without claiming causation
- Bifidobacterium longum BB536 shows no significant effect on GI symptoms in athletes on high-protein diet
- L-taurine shows no overall fatigue benefit in decompensated cirrhosis but may help non-anemic patients
- Ketotifen shows significant improvements in hepatic steatosis and fibrosis indices compared with vitamin E in a pilot study of NAFLD
- Systematic review finds gut microbiota drugs reduce liver enzymes in MASLD patients compared to placebo
- Cochrane review finds vitamin D may slightly reduce ARI healthcare visits in children
- Oral microbiome profiles differ by periodontitis stage in Korean adults
- Protocol for TEAS adjunct with PEG in elective colonoscopy bowel preparation
- Review of genetic risk haplotypes in Celiac disease across diverse ancestries
- Deep Learning and Explainable AI in Cancer Immunotherapy: A Review of Biomarker Integration
- Systematic review links periodontitis to NAFLD progression and HCC risk
- Vaginal hyaluronic acid associated with epithelial transformation in symptomatic benign cervical ectopy
- Systematic review on neuroimmune mechanisms in preeclampsia
- Observational study links metabolites, microbiota, and brain connectivity in functional dyspepsia
- Preoperative model predicts lateral lymph node metastasis in rectal cancer
- IM-PAC Grading Correlates with Chronic Pancreatitis Severity on CT and MRI
- Integrative review of Epimedium flavonoids in hepatitis and cirrhosis shows preclinical promise but lacks clinical validation
- Meta-analysis of 55 studies assesses HCV prevalence trends across Eastern Mediterranean Region populations
- Scoping review identifies health system components reducing avoidable IBD admissions via access and self-management support
- Narrative review covers IBD, bile acid malabsorption, IBS-D, CRC, obesity, NAFLD, and sepsis-related intestinal injury
- Narrative Review Synthesizes Evidence on Extracellular Vesicles for Premature Ovarian Insufficiency and Testicular Damage
- Narrative review discusses M cell manipulation limitations in inflammatory bowel disease models
- Literature review synthesizes Schisandra chinensis effects on gut microbiota and metabolic pathways across multiple conditions
- Probiotics shorten hospital stay and improve gut recovery after open gastrectomy for gastric cancer
- FMT shifts bile acids faster than vancomycin in recurrent C. difficile infection subgroup
- Observational study maps sex-specific molecular architectures in MASLD using multi-omics profiling
- Narrative review outlines mitochondrial organelle interactions in acute pancreatitis pathogenesis
- Review of secondary analysis on IBS predictors in Bangladeshi students
- Hypertension associated with specific reduction of NK subpopulation in male subjects
- Electroacupuncture at ST36, ST37, and PC6 may shorten recovery times after laparoscopic gastrectomy for gastric cancer
- Cross-sectional data suggest IgG glycans discriminate inflammatory bowel disease from controls
- Review of MASLD without reported population data or specific outcomes
- Narrative review examines TCM herbal extracts and formulas regarding cholestatic liver injury
- Meta-analysis of 7,750 saliva samples validates non-invasive disease prediction models for nasopharyngeal carcinoma, colorectal cancer, and PLHIV
- Gemcitabine exposure associated with higher TP53 and PI3K pathway alterations in pancreatic ductal adenocarcinoma tumors
- Meta-analysis of 9 studies estimates HCV seroprevalence of 3.63% among African refugees and displaced persons
- Scoping review of 60 sources in LMICs identifies barriers to AI adoption and governance gaps
- Fecal microbiota transplantation shows efficacy for recurrent C. difficile infection, IBD, and autism spectrum disorder in children
- Narrative review examines perinatal microbiota influences and evidence gaps in dogs and cats
- Network meta-analysis compares preventive measures for esophageal variceal bleeding in 6510 cirrhosis patients
- Review links oral microbiome dysbiosis to malignant transformation in oral lichen planus
- Narrative review outlines clinical framework for managing primary Sjögren's disease with interstitial lung disease
- Immune checkpoint inhibitor regimens improve survival versus tyrosine kinase inhibitor monotherapies in advanced hepatocellular carcinoma
- Robotic simultaneous resection for synchronous colorectal cancer and liver metastases shows feasibility and safety in a meta-analysis
- Systematic review examines immunological analysis of Blau syndrome pathogenesis to define treatment pathways
- Single-cell sequencing reveals T cell clonal patterns in healthy donors and ulcerative colitis patients
- Gastotypes predict Helicobacter pylori infection status in gastric mucosal samples with high accuracy
- Regorafenib plus nivolumab in second-line hepatocellular carcinoma showed safety and survival signals in a Phase IIa trial
- Phase I trial of regorafenib plus ipilimumab and nivolumab shows 27.6% response in MSS colorectal cancer
- Systematic review of pediatric post-COVID-19 condition mechanisms and clinical presentations in children and adolescents
- Colon-targeted riboflavin altered fecal microbiome composition in healthy older adults over 12 weeks
- Rituximab exposure is associated with serum sickness in patients with multiple sclerosis, nephrotic syndrome, or immune thrombocytopenia
- Seladelpar shows improved composite endpoint and ALP reduction in PBC with compensated cirrhosis
- Quantitative susceptibility mapping shows higher deep gray matter alterations in Wilson's disease compared to healthy controls
- Network meta-analysis shows image-enhanced endoscopy methods improve adenoma detection rates compared to high-definition white light imaging in colorectal lesion screening
- Immune Checkpoint Inhibitors Improve Survival and Response Rates in Patients with Hepatocellular Carcinoma Compared to Standard Therapy
- Meta-analysis finds exercise training reduces intrahepatic lipids and improves metabolic markers in NAFLD
- Blood group B alleles associated with increased MIS-C risk in Italian children cohort study
- Hepatitis E vaccine linked to elevated spontaneous abortion risk when given 31-60 days before pregnancy
- Phase 2 trial of JNJ-73763989-based regimen shows no HBsAg seroclearance at primary endpoint in HBeAg-positive CHB
- Wearable monitoring characterizes autonomic dysfunction in hypermobile Ehlers-Danlos syndrome compared to healthy controls
- Vitamin D supplementation associated with improved metabolic markers in patients with Metabolic-Associated Fatty Liver Disease
- SBRT plus PD-1 inhibitor and lenvatinib improved PFS in oligoprogressive HCC patients
- Machine learning models show moderate to high accuracy for predicting variceal bleeding in cirrhosis patients
- Diet-induced liver fat reduction associated with fasting metabolite changes but not postprandial responses
- Nurse-assisted outpatient follow-up reduces 30-day readmissions but not mortality in decompensated cirrhosis
- Cognitive-behavioral sleep intervention with nutritional support improves sleep, survival in rectal cancer surgery patients
- Laparoscopic hemihepatectomy shows higher costs but better QALYs than open approach in European trial
- Endoscopic findings predict advanced gastric signet ring cell carcinoma in CDH1 carriers
- SBCE as initial investigation reduces DBE referrals in suspected small bowel Crohn's disease cohort
- Network meta-analysis finds pegozafermin, OCA, and resmetirom outperform placebo for MASLD fibrosis improvement
- Antenatal pelvic floor exercise reduces perineal laceration risk in primiparous women during vaginal delivery
- Meta-analysis finds fatty pancreas disease in over half of adults with MASLD
- Laparoscopy-assisted trans-umbilical Meckel's diverticulectomy described in pediatric case series
- First-in-human study finds VS-01 generally well tolerated in decompensated cirrhosis with ascites
- CAM products associated with ACLF in 39.6% of patients with liver injury in retrospective cohort
- Metabolomics analysis reveals distinct B-cell metabolic signatures in IgG4-RD patients compared to healthy controls
- Serological assays show high concordance for detecting celiac disease-specific autoantibodies in a Tunisian cohort
- Thymosin alpha1 added to standard therapy improved 90-day transplant-free survival in 73 patients with HBV-related acute-on-chronic liver failure
- Network meta-analysis ranks exercise types for colorectal cancer survivors post-resection based on specific outcomes
- Hyperferritinemia is associated with higher liver-related event incidence in patients with metabolic dysfunction-associated steatotic liver disease
- Carbapenem-resistant hypervirulent Klebsiella pneumoniae infection is associated with significantly higher mortality compared to carbapenem-susceptible strains in 4240 patients
- Efruxifermin shows superior fibrosis regression in compensated MASH cirrhosis compared to placebo in a network meta-analysis
- Web portal developed for personalized colorectal cancer risk prediction using genetic and lifestyle factors
- Return to drinking occurs in 22% of alcohol-associated hepatitis patients within 90 days of recovery
- Regular antithrombotic use associated with increased nonbiliary pancreatitis risk in UK Biobank cohort
- Meta-analysis links higher BMI to increased early-onset colorectal cancer risk
- Oral nutritional interventions associated with reduced clinical events in adults with cirrhosis
- AI web app feedback improves bowel preparation quality in outpatient colonoscopy RCT
- Dynamic ctDNA monitoring during neoadjuvant chemotherapy identifies high-risk rectal cancer patients
- New-onset diabetes in adults over 50 associated with higher pancreatic cancer risk within 3 years
- In Silico Modeling Predicts Fezolinetant Hepatotoxicity Risk in MAFLD Population