Meta-analysis finds mixed MRI patterns in subgenual cingulate cortex in medication-free MDD patients
What does depression look like in the brain? The picture is complicated
A systematic review and meta-analysis of 42 publications compared medication-free MDD patients to healthy controls using MRI.
Depression scans show mixed results for brain size and activity, but consistently reveal weaker connections in an emotional hub when the bra…
Protocol for RCT of sequential aTBS for suicidal ideation in adults with MDD
Study protocol tests brain stimulation for depression with suicidal thoughts
This is a study protocol for a single-blind RCT of 56 adults with major depressive disorder and active suicidal ideation.
A new brain stimulation treatment is being tested to reduce depression and suicidal thoughts in adults, using magnetic pulses over 10 sessio…
Inflammatory markers elevated in adolescent MDD with both self-injury and suicide attempts
Could a simple blood test help identify teens at highest risk for self-harm?
A retrospective cross-sectional study of 618 adolescent inpatients with MDD found those with comorbid non-suicidal self-injury and suicide a…
Teens with depression who self-harm and attempt suicide show distinct blood markers, offering a potential clue to identify those at highest …
LSD Microdosing Shows Mood Improvement in Major Depressive Disorder: Phase 2a Trial
Can microdosing LSD really boost mood in people with depression?
An open-label trial of microdosed LSD in major depressive disorder showed mood improvements on dosing days (p = 0.009 to 0.039) but no chang…
People with depression taking microdosed LSD for eight weeks reported feeling happier and more creative on dosing days while symptoms droppe…
Phase 2 Trial of Icalcaprant for MDD: Assessing Efficacy and Safety
Could This New Drug Help Ease Severe Depression Symptoms?
A Phase 2 trial is evaluating the efficacy and safety of oral Icalcaprant in 195 adults with MDD. Primary outcomes include changes in MADRS …
A new drug called Icalcaprant is being tested to see if it can help adults with major depressive disorder who are currently experiencing a m…
Serum Zinc and Iron Levels Reduced in MDD; Copper Levels Elevated
Could Missing Nutrients Be Worsening Your Depression?
Meta-analysis of 16 studies shows MDD patients have lower serum zinc (SMD = -0.62; 95% CI: -0.78 to -0.46) and iron (SMD = -0.36; 95% CI: -0…
People with depression often have lower zinc and iron but higher copper levels in their blood, suggesting nutrition plays a key role in mana…