Vitamin D supplementation may reduce disease activity in SLE: a systematic review and meta-analysis
Vitamin D supplements may calm lupus activity, study finds
This systematic review and meta-analysis of 847 patients with systemic lupus erythematosus found that vitamin D supplementation significantl…
A new analysis of 847 lupus patients suggests vitamin D supplements may reduce disease activity and improve immune markers.
Narrative review of transposable element methylation in autoimmune diseases
Genetic elements may link autoimmune diseases to inflammation
This narrative review examines the role of transposable element (TE) methylation and expression in Type 1 diabetes, systemic lupus erythemat…
Changes in certain genetic elements could explain how the body triggers inflammation in diseases like lupus and rheumatoid arthritis.
Umbrella review identifies risk factors and protective factors for male infertility and semen quality
New study lists many things that hurt male fertility and health
This umbrella review of 43 studies synthesizes evidence on risk factors for male infertility and abnormal semen parameters.
A new review shows that obesity, smoking, and certain illnesses can hurt sperm, but healthy habits might fix the problem.
Meta-analysis of belimumab versus anifrolumab in systemic lupus erythematosus and lupus nephritis
Belimumab and anifrolumab show different strengths for lupus patients
This meta-analysis compared belimumab and anifrolumab using indirect evidence from randomized controlled trials involving 4332 patients with…
A new analysis compares two lupus drugs. Belimumab worked better for overall disease control, while anifrolumab helped lower steroid doses a…
Meta-analysis links CYP2C19*2 polymorphism to reduced cyclophosphamide toxicity in SLE
Genetic marker may lower risk of cyclophosphamide toxicity in lupus patients
This meta-analysis of 5 observational studies found that the CYP2C19*2 genetic polymorphism is associated with a protective effect against…
A genetic variant linked to lower risk of cyclophosphamide side effects in lupus patients, though evidence remains limited by small study si…
Telitacicept plus standard therapy in SLE patients with antiphospholipid antibodies
New Lupus Drug May Help Patients With Specific Antibodies
This prospective observational cohort study evaluated telitacicept added to standard therapy in 20 SLE patients with antiphospholipid antibo…
A new treatment shows promise for a tough lupus group by targeting specific immune cells.
Narrative review explores TLR7 and TLR9 signaling networks within systemic lupus erythematosus and Sjögren's disease contexts
Why Lupus and Sjögren’s Flares May Start in Your Cells’ “Mailroom”
This narrative review examines the role of TLR7 and TLR9 signaling networks in systemic lupus erythematosus and Sjögren's disease.
Understanding how these immune sensors misfire could lead to more precise treatments that calm flares without shutting down your whole immun…
Narrative review discusses screening and prevention in rheumatic and musculoskeletal disease populations
Joint Pain May Signal Hidden Risk in Your Legs
This narrative review examines patients with rheumatic and musculoskeletal diseases (RMDs), including rheumatoid arthritis and systemic lupu…
Inflammation from autoimmune conditions can silently damage blood vessels in your legs.
Narrative mini-review discusses mechanisms driving coronary atherosclerosis in patients with systemic lupus erythematosus
Why Lupus Can Speed Up Heart Disease, Even in Young People
This narrative mini-review synthesizes mechanistic insights regarding the link between systemic lupus erythematosus and coronary atheroscler…
Understanding how lupus harms blood vessels could help prevent heart attacks in people who don’t look high-risk.
Systematic review of immunosuppression for SLE-associated intestinal pseudo-obstruction
SLE Can Shut Down the Gut — But It Might Be Reversible
This review synthesized 43 cases of SLE-associated intestinal pseudo-obstruction.
Lupus can paralyze the gut without a blockage, but early treatment with immunosuppressives often reverses this dangerous complication.
Obesity associated with reduced SLE relapse rates in Japanese registry cohort
A Surprising Link Between Weight and Lupus Flares
This observational cohort study of 1134 patients with systemic lupus erythematosus in Japan found that obesity (BMI ≥25 kg/m2) was associate…
Being overweight or mildly obese might lower the risk of lupus relapses, challenging common beliefs about weight and autoimmune disease.
Narrative review explores emerging therapeutic strategies targeting Th17 and Treg balance in systemic lupus erythematosus
Could new drugs restore balance for lupus patients, or is the science still too early?
This narrative review examines emerging therapeutic strategies aimed at restoring the Th17 and Treg balance in patients with systemic lupus …
Doctors are exploring new drugs to restore balance between immune cells in lupus, aiming to stop attacks without shutting down the entire sy…