Doctors tested a new medicine called olezarsen in adults who had moderate levels of triglycerides in their blood. The goal was to see if the drug could shrink the fatty buildup inside arteries. A total of 468 people took part in this test.
For twelve months, half the group took olezarsen while the other half took a placebo. Scientists measured how much plaque changed in the arteries of everyone involved. They looked at soft plaque, hard plaque, and the total amount of buildup.
The results showed no real difference between the two groups. The amount of plaque changed by about the same amount whether people took the new drug or the dummy pill. No serious safety problems were found in either group during the study.
This means olezarsen did not work better than a placebo for this specific goal. Doctors will need to look for other ways to help lower plaque in patients with high triglyceride levels.