Medical Reviewer
Dr. Amelia Tan, PhD
Internal Medicine & Chronic Disease — Organ-system RCTs, biomarker endpoints, immune-mediated disease, biologics.
Dr. Amelia Tan is a freelance medical writer based in Singapore with over 10+ years of experience in clinical research, regulatory writing, and pharmaceutical communications, specializing in Internal Medicine & Chronic Disease. She holds a PhD in Biomedical Sciences from the National University of Singapore and a Master's degree in Clinical Research from Nanyang Technological University. She also holds certification in Good Clinical Practice (ICH-GCP) and regulatory writing standards.
Amelia's expertise spans organ-system clinical trials and biologic therapies, with a focus on cardiology, endocrinology, nephrology, pulmonology, gastroenterology, hematology, rheumatology, and immune-mediated diseases. She has extensive experience working with randomized controlled trials involving biomarker endpoints and chronic disease progression models.
Prior to transitioning into freelance writing, Amelia worked as a Clinical Research Scientist at a global pharmaceutical company, where she led multi-center trials across Southeast Asia. She is known for her ability to translate complex clinical datasets into clear, compliant, and publication-ready scientific content for regulatory authorities, clinicians, and research teams.
Articles in this group — last 14 days
Guideline on severe pediatric obesity with MC4R variant and puberty management
Two siblings with severe obesity and early puberty found to have genetic changes affecting their growth and health over fourteen years
This guideline, based on a case report of two Chinese siblings with a heterozygous MC4R variant, synthesizes long-term management of monogen…
Two Chinese brothers with severe obesity and early puberty received special treatments for fourteen years. Their puberty slowed down, blood …
Meta-analysis shows association between adequate antimicrobial therapy and reduced hospital length of stay
Right Antibiotic Choice Cuts Hospital Stay by Nearly Two Weeks
This meta-analysis of 4158 adult hospitalised patients examines the relationship between adequate empirical antibiotic therapy and clinical …
Choosing the right antibiotic from the start can cut a hospital stay by nearly two weeks for adults with serious infections.
Endoscopic submucosal dissection outperforms precut mucosal resection for colorectal polyp removal
Doctors find ESD works better than precut cuts for big polyps
A meta-analysis of 1,460 patients reveals that ESD provides superior en bloc resection compared to EMR-P.
A new review shows endoscopic submucosal dissection removes colorectal polyps more cleanly without adding extra risk to patients.
Systematic review and meta-analysis of interim FDG PET in large B-cell lymphoma patients
Early PET scans help doctors predict how well large B-cell lymphoma treatments will work for patients
This systematic review and meta-analysis evaluated the utility of interim FDG PET (iPET) in 44 eligible studies involving large B-cell lymph…
A review of many studies shows that early PET scans can tell doctors if cancer treatment is working. This helps them decide the best next st…
Surgical resection shows superior survival outcomes compared to radiofrequency ablation for small hepatocellular carcinoma cases
Surgery offers better long-term survival and lower recurrence rates for small liver cancer cases compared to ablation
A meta-analysis of 3,551 patients indicates surgical resection offers significantly better long-term survival than radiofrequency ablation f…
A review of 3,551 patients found surgery works better than ablation for small liver tumors. People who had surgery lived longer and had fewe…
Sacubitril/Valsartan plus RFCA improves rhythm control in hypertensive NPAF patients
ARNI plus RFCA improves heart rhythm control in hypertension patients
This randomized controlled trial in 240 hypertensive patients with nonparoxysmal atrial fibrillation compared sacubitril/valsartan plus radi…
Adding sacubitril/valsartan to a heart procedure helped more patients stay in normal rhythm and lowered blood pressure markers.
Bismuth quadruple therapy shows higher H. pylori eradication in pediatric patients with clarithromycin resistance
High-Level Clarithromycin Resistance May Predict Bismuth Success in H. pylori
This observational study of 4,610 pediatric patients with H. pylori infection compared bismuth quadruple therapy to triple therapy. Bismuth …
A simple blood test level may predict which H. pylori infections respond best to bismuth therapy, turning a treatment failure sign into a gu…
Propofol-first sequence reduces hypoxemia in obese patients undergoing gastroscopy
Giving anesthesia in a new order cuts oxygen risk for obese patients
This single-center RCT compared propofol-first versus remifentanil-first sedation sequences in obese patients undergoing gastroscopy. The pr…
A new drug sequence cuts low oxygen events by nearly half in obese patients getting gastroscopy sedation.
FDA Approves Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) for COPD Maintenance
FDA approves new triple-combination inhaler Breztri Aerosphere for COPD.
The FDA approved Breztri Aerosphere (budesonide/glycopyrrolate/formoterol fumarate) for maintenance treatment of COPD. It is a triple-combin…
The FDA approved Breztri Aerosphere, a triple-combination inhaler, for the long-term treatment of chronic obstructive pulmonary disease (COP…
FDA Approves Epysqli (eculizumab-sbja) for PNH, aHUS, and gMG
FDA approves new drug Epysqli for three rare blood and nerve conditions.
The FDA approved Epysqli (eculizumab-sbja) for paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and gen…
The FDA approved Epysqli (eculizumab-sbja) for paroxysmal nocturnal hemoglobinuria, atypical hemolytic uremic syndrome, and generalized myas…
Bayesian network meta-analysis of seven debridement approaches for diabetic foot ulcers shows low certainty evidence
New data ranks debridement methods for healing diabetic foot ulcers faster
This Bayesian network meta-analysis evaluated seven debridement approaches versus standard wound care for individuals with diabetic foot ulc…
New research shows biological and enzymatic debridement methods shrink diabetic foot ulcers the most, but experts warn the evidence is not y…
Induction of Labor Reduces Shoulder Dystocia in Suspected Large-for-Gestational-Age Fetuses: Meta-Analysis
Induction of labor reduces shoulder dystocia in suspected large babies
This systematic review and meta-analysis of 4,083 pregnant individuals at ≥35 weeks with suspected LGA fetuses found that induction of labor…
A large analysis suggests inducing labor for suspected large babies lowers the risk of shoulder dystocia and cesarean delivery compared to s…
Acupuncture and moxibustion cake may reduce thyroid antibodies in Hashimoto thyroiditis
Acupuncture May Lower Thyroid Antibodies in Hashimoto Patients
A meta-analysis suggests acupuncture and moxibustion cake may lower thyroid antibodies in Hashimoto thyroiditis, but evidence is limited.
Acupuncture and moxibustion may lower thyroid antibodies in Hashimoto patients, but the evidence is still early and limited.
Cross-sectional gene-diet interaction study on fish oil and omega-3 levels in UK Biobank
Your genes determine how well fish oil boosts your heart health
This is a cross-sectional gene-diet interaction study using UK Biobank data. It found that fish oil supplementation was associated with high…
New research shows that your DNA determines how much extra omega-3 you get from eating fish or taking supplements
High ultra-processed food diet alters adolescent brain reward response to milkshake
Ultraprocessed foods dull teen brains in just two weeks
This randomized controlled crossover trial in emerging adults aged 18 to 25 compared a high-UPF diet to a non-UPF diet. The main finding was…
Teens’ brains respond less to food rewards after eating ultraprocessed foods for only two weeks, raising concerns about long-term eating hab…
Review of environmental exposures in agricultural communities with chronic kidney disease of unknown cause
New research hunts the hidden causes of kidney disease in farming communities
This publication is a review examining potential environmental exposures in agricultural communities in Central America and South Asia. The …
A new study hunts for the hidden causes of kidney disease in farming communities across Central America and South Asia.
Early magnesium sulphate catharsis reduces severe acute pancreatitis and mortality in high-risk patients
Early Magnesium Sulfate Treatment May Stop Pancreatitis From Turning Deadly
This clinical retrospective cohort study evaluated 850 patients with acute pancreatitis at high risk of systemic complications. Early magnes…
Early magnesium sulfate treatment may prevent severe pancreatitis and save lives, a large new study suggests.
Resistance Training with Photobiomodulation Improves Muscle Strength in Difficult-to-Control Asthma
A Light Therapy Boosts Muscle Strength in Tough Asthma
This small RCT in 30 adults with difficult-to-control asthma found that adding LED-based photobiomodulation to resistance training improved …
Adults with hard-to-treat asthma built more muscle strength when resistance training was paired with a safe LED light therapy.
Liposuction I/A ratios of 0.8 to 1.1 optimize postoperative satisfaction and reduce bruising in patients
Finding the perfect fluid mix makes liposuction safer and less painful for patients
This randomized controlled trial evaluated patients who have undergone liposuction. The study compared varying ratios of infiltration fluid …
A specific fluid mix during liposuction reduces pain and swelling while keeping patients comfortable and safe
Amiloride and hydrochlorothiazide affect metabolites and ammonium excretion in CKD patients
Distal diuretics change kidney chemistry in people with chronic kidney disease
This randomized controlled trial in 26 individuals with chronic kidney disease found that distal diuretics decreased plasma glutamine and tr…
A small trial found that taking amiloride and hydrochlorothiazide lowered glutamine and changed how the body handles waste in people with ch…
Narrative review of transposable element methylation in autoimmune diseases
Genetic elements may link autoimmune diseases to inflammation
This narrative review examines the role of transposable element (TE) methylation and expression in Type 1 diabetes, systemic lupus erythemat…
Changes in certain genetic elements could explain how the body triggers inflammation in diseases like lupus and rheumatoid arthritis.
Meta-analysis shows associations between hypothyroidism and increased chronic kidney disease prevalence
Hypothyroidism Linked To Kidney Issues But Treatment Does Not Fix Them
This meta-analysis of 46 studies examines the relationship between hypothyroidism, including subclinical cases, and kidney outcomes.
Untreated low thyroid levels are strongly tied to worse kidney function in adults, but taking thyroid medicine does not seem to improve kidn…
Meta-analysis and cohort study suggest association between SGLT2 inhibitors and reduced arrhythmia recurrence
SGLT2 Inhibitors Cut AF Recurrence And Improve Heart Function After Ablation
This meta-analysis and retrospective cohort study examined the association between SGLT2 inhibitors and atrial arrhythmia recurrence after c…
New data shows SGLT2 inhibitors lower the risk of irregular heartbeats returning after surgery while strengthening heart muscle in patients …
Meta-analysis shows linezolid-containing regimens for multidrug/rifampicin-resistant tuberculosis
Linezolid helps treat drug resistant tuberculosis
This meta-analysis of 3019 patients evaluates the efficacy and safety of linezolid-containing regimens compared to standard of care for…
New evidence shows that adding linezolid to treatment helps patients with drug resistant tuberculosis achieve better health outcomes.
Pilot Study Shows 2% Salicylic Acid Shampoo Reduces Scab Severity in Androgenetic Alopecia Patients
Simple wash removes scabs after hair transplant surgery
This prospective, multicenter, single-arm pilot study evaluated 21 male patients using a 2% salicylic acid shampoo.
A new shampoo formula helps clear scabs after hair transplant surgery without causing pain or irritation for most patients.
Machine Learning Model Improves Prediction of Detrusor Underactivity in BPH Patients
Smart computer program spots bladder weakness before prostate surgery starts
This retrospective cohort study of 538 urodynamically evaluated BPH patients found that an interpretable machine learning model (XGBoost) ou…
A new computer system predicts bladder weakness in men with prostate problems before they go under the knife for surgery.
Sequential SBRT, pembrolizumab, and resection in oligometastatic colorectal cancer shows 60% 1-year RFS
Phase Ib trial shows promising signs for colorectal cancer treatment
This Phase Ib clinical trial evaluated sequential stereotactic body radiotherapy, pembrolizumab, and resection in 15 patients with oligometa…
A Phase Ib trial found that a specific combination therapy helped 60% of patients stay free from cancer recurrence for one year.
Review of animal models shows unclear causal links between microbial dysbiosis and pulmonary fibrosis
Your Gut Microbes May Shape Lung Fibrosis Treatment
This review examined animal models regarding pulmonary fibrosis.
Your gut microbes may influence lung scarring, opening new paths for treatment beyond current drugs.
Perspective review discusses chronic air pollution effects on children and older adults in Puerto Rico
Air pollution may change your body’s microbes and raise cancer risk
This perspective review examines the impact of chronic air pollution and environmental exposures on children and older adults.
Tiny particles in the air we breathe may be altering the body’s microbiome and increasing cancer risk, especially in kids and older adults l…
Higher dietary inflammation linked to increased COPD risk in UK Biobank cohort
Your diet could be fueling your COPD risk
This prospective cohort study of 167,440 UK Biobank participants found that higher Dietary Inflammatory Index (DII) and Energy-adjusted DII …
What if the food on your plate is quietly raising your risk for breathing problems, even if you’ve never smoked?
RNK08954 shows unconfirmed responses in KRASG12D-mutant NSCLC and PDAC in Phase Ia trial
New drug shows promise for KRASG12D lung and pancreatic cancers
This phase Ia trial evaluated RNK08954 in 36 patients with KRASG12D-mutant non-small cell lung cancer or pancreatic ductal adenocarcinoma.
An early trial of RNK08954 shrank tumors in 58% of lung cancer patients with a specific KRAS mutation.
Subcutaneous tislelizumab shows comparable trough concentrations to intravenous dosing in treatment-naive advanced non-small cell lung cancer patients
Phase I trial shows subcutaneous tislelizumab reaches high drug levels in lung cancer patients
This phase I trial evaluated subcutaneous versus intravenous tislelizumab in treatment-naive patients with advanced non-small cell lung canc…
Early data suggest subcutaneous tislelizumab injections may offer similar drug levels to intravenous forms for treating advanced lung cancer…
Evidence-based review of transducer selection for lung ultrasound in dogs and cats with pulmonary pathology
Choosing the right ultrasound probe can improve lung diagnoses for dogs and cats
This evidence-based review examines transducer selection for lung ultrasound in dogs and cats with pulmonary pathology.
Veterinary lung ultrasound accuracy depends on probe choice. This review highlights how transducer selection affects diagnosis in emergency …
Nephrometry Scores Show Limited Discrimination for Adverse Outcomes After RAPN in Larger Renal Tumors
Tumor complexity scores predict longer surgery time but not major complications in kidney cancer removal
This retrospective cohort study of 109 patients with pT1b–pT2a renal tumors found that PADUA and RENAL nephrometry scores had limited discri…
Scores measuring kidney tumor complexity predicted longer surgery time but failed to predict major complications in 109 patients.
Pre-admission statin use linked to better 30-day outcomes after aneurysmal SAH
Pre-admission statin use linked to better 30-day outcomes in brain bleed patients
This observational study of 1,431 patients with aneurysmal subarachnoid hemorrhage found that pre-admission statin use was associated with a…
Using statins before a brain bleed may improve early recovery chances, but benefits did not last to 90 days in this real-world study.
BIPON framework shows effectiveness on benchmark imaging assessment tasks in public knee MRI benchmarks
BIPON framework shows promise for imaging-based injury assessment tasks
This cohort study evaluated the Biomechanical Informed Predictive Optimization Network (BIPON) framework using public knee MRI benchmarks.
A new imaging framework called BIPON demonstrated effectiveness on benchmark assessment tasks, though its components lack current empirical …
Deep Learning Reconstruction EOB-MRI detects more small low-signal lesions than standard non-DL MRI in 53 patients
Deep Learning MRI Finds More Small Liver Lesions Than Standard Scans
This prospective, single-center study evaluated 53 patients undergoing EOB-MRI during the hepatobiliary phase.
A new scan method using deep learning found more tiny liver spots than traditional imaging, though larger spots were detected equally well.
Risk prediction model for adhesive intestinal obstruction after laparoscopic appendectomy
Laparoscopic surgery for appendicitis may raise risk of future bowel blockage
This retrospective cohort study of 298 patients who underwent laparoscopic surgery for acute appendicitis found that those who developed adh…
A new look at 298 patients found that laparoscopic surgery for appendicitis was linked to higher rates of future bowel blockage compared to …
Scoping review finds SGLT2 inhibitors show kidney protection in IgA nephropathy
Two major trials show kidney-protective effects for a specific IgA nephropathy group
This scoping review synthesizes evidence on SGLT2 inhibitors in IgA nephropathy.
Two large trials found kidney-protective effects for some IgA nephropathy patients taking SGLT2 inhibitors, while real-world data showed red…
Review of IVIG and bronchoscopic interventions for pediatric EBV-SMT in immunodeficiency
A rare lung tumor in a boy with immune issues may need IVIG and bronchoscopic procedures
This case report review describes a 10-year-old boy with congenital immunodeficiency and an Epstein–Barr virus-associated smooth muscle tumo…
A single case report suggests IVIG and bronchoscopic procedures might help a rare lung tumor in children with immune problems, though recurr…
Network meta-analysis finds exercise therapies reduce depressive symptoms in post-stroke depression
Exercise therapies reduce depression and improve function after stroke
This systematic review and network meta-analysis of 2,339 patients found that various exercise therapies significantly reduce depressive sym…
A network meta-analysis of nearly 2,400 patients found exercise therapies significantly reduce depressive symptoms and improve daily living …
Machine learning predicts recreational therapy engagement in veterans
Veterans at Risk of Isolation Can Be Found Early
This cross-sectional study of 57 veterans used machine learning to predict recreational therapy engagement.
New computer models can spot veterans at risk of isolation so staff can help them join fun activities sooner.
Systematic review and meta-analysis finds high prevalence of ocular manifestations in leukemia patients
Leukemia patients face eye risks that doctors must spot early now
This systematic review and meta-analysis of 1016 patients with leukemia found a 42% prevalence of overall ocular manifestations.
New data shows almost half of leukemia patients have eye issues, so regular eye checks are essential for better care
Combination TACE plus systemic therapy showed no PFS benefit but improved OS in BCLC-C HCC patients compared to TACE alone
Combination therapy improves survival for advanced liver cancer patients in one study
This retrospective cohort study evaluated 142 patients with intermediate or advanced-stage hepatocellular carcinoma at Hunan Provincial Peop…
Combination therapy may extend life for advanced liver cancer patients, but results vary by disease stage and need more research.
Global MS burden in women of childbearing age rises 48% from 1990 to 2021
Multiple sclerosis rates rose sharply in women of childbearing age from 1990 to 2021
A global cohort analysis of 204 countries found that multiple sclerosis incidence in women aged 15–49 rose 48% from 1990 to 2021, with preva…
Multiple sclerosis cases and deaths increased among women of childbearing age globally, though disability years dropped slightly.
Modified prednisone regimen shows short-term ineffectiveness in infantile epileptic spasms syndrome based on retrospective cohort data
Blood marker may predict prednisone response in infantile spasms
This retrospective cohort study evaluated 66 IESS patients and 53 age-matched healthy controls.
A blood protein called HMGB1 may help doctors quickly tell if prednisone will work for infantile spasms.
Review of ovarian cancer treatments including olaparib, bevacizumab, and durvalumab discusses limitations and biomarkers
New drug combos target hidden cancer switches to stop resistance
This narrative review examines ovarian cancer management involving olaparib, bevacizumab, and durvalumab.
Hidden chemical changes in ovarian cancer cells help them hide from drugs, but new combinations might finally stop them from adapting and gr…
Narrative review discusses NF-kB inhibition for inflammatory bowel diseases and related conditions
Blocking NF-κB May Ease Gut Inflammation in IBD
This narrative review explores the role of NF-kB pathway inhibition in treating inflammatory conditions.
A review finds that blocking a key inflammatory pathway could help treat Crohn's, colitis, and celiac disease.
Narrative review explores ferroptosis-immune crosstalk in CNS diseases as therapeutic target
New hope for brain diseases by targeting a deadly cell death cycle
This narrative review synthesizes evidence on the interplay between ferroptosis and immune responses in CNS disorders including Alzheimer's,…
Scientists found a way to stop a deadly cell death cycle that makes brain diseases worse, offering new hope for patients with Alzheimer's an…
Review finds higher ambient temperature linked to lower viral gastroenteritis rates in children
Hotter weather may lower the chance of viral stomach bugs in children
This secondary analysis of a prospective multisite study reviews the association between environmental exposures and viral gastroenteritis i…
Higher temperatures were linked to fewer viral stomach bugs in children, suggesting weather patterns matter for health.
Nurse-led lifestyle interventions improve quality of life and reduce AF recurrence after ablation
Nurse-led care reduces AF recurrence and boosts quality of life after ablation
This randomized controlled trial of 160 patients undergoing radiofrequency ablation for paroxysmal atrial fibrillation found that nurse-led …
Patients receiving nurse-led lifestyle support after heart rhythm surgery had fewer AF recurrences and better quality of life than those rec…
Nurse-led peer support improved psychological status and quality of life in patients with acute myocardial infarction
Nurse-led support lowers stress and boosts well-being for heart attack patients
This randomized controlled trial enrolled 200 patients with acute myocardial infarction who underwent stent implantation in China.
Twelve weeks of nurse-led group sessions significantly reduced anxiety and depression while improving emotional well-being for patients reco…
Vegetarianism associated with altered lipid profiles in UK Biobank participants
Vegetarian diets lower cholesterol in UK Biobank participants
This cross-sectional study of UK Biobank participants found that vegetarianism was associated with reduced total, LDL, and HDL cholesterol b…
Vegetarian diets were linked to lower cholesterol levels in a large UK study. This finding applies to people of European, Asian, and African…
Mediterranean diet plus physical activity reduces postprandial triglyceridemia in adults with abdominal obesity
Combining diet and exercise may lower blood fat better than either alone
This randomized controlled trial enrolled two hundred men and women with abdominal obesity and moderate hypertriglyceridemia.
Combining a Mediterranean diet with regular exercise may lower blood fat levels better than doing just one, offering a small but promising b…
Weight Regain Reverses Caloric Restriction Benefits on Insulin-IGF-1 Pathway and Biological Age
Weight Regain Undoes Caloric Restriction Benefits For Diabetes Risk
This post hoc analysis of the CALERIE-2 trial examined 190 participants who underwent 25% caloric restriction or control diet.
Losing weight helps control diabetes risk, but gaining those pounds back undoes the hormonal benefits and reverses progress made during the …
Wholegrain rye diets improve metabolic markers but not weight loss in overweight adults
Wholegrain rye lowers inflammation better than refined wheat for weight loss diets
This 12-week randomized trial compared hypocaloric diets with wholegrain rye versus refined wheat in 255 adults with overweight or obesity.
Switching to wholegrain rye while dieting may lower inflammation and improve gut bacteria even if weight loss is the same
Resistance exercise and high protein diet improved metabolic flexibility in older men over 12 weeks
Resistance exercise and high protein diet improved metabolic flexibility in older men
This randomized controlled trial involved 33 older men.
A 12-week trial found that resistance exercise and high protein diet improved metabolic flexibility in older men compared to doing nothing.
Two-year caloric restriction attenuated biological age increases across multiple organ systems in a randomized trial
Eating Less Slows Aging in Heart and Metabolism Systems
This Phase 2 randomized controlled trial evaluated 185 participants assigned to sustained caloric restriction or an ad libitum diet.
Eating less food may actually slow down aging in your heart and metabolism while keeping other organs stable.
Energy restriction with ultra-processed food restriction yields greater weight loss than generic energy restriction in obesity
Low-Processed Food Diet May Help People With Obesity Lose More Weight
This randomized clinical trial enrolled 148 individuals with obesity and compared energy restriction associated with ultra-processed food re…
A trial found that restricting ultra-processed foods alongside calorie limits helped people with obesity lose more weight and reduce ultra-p…
Semaglutide reduces insulin dose in adults with type 1 diabetes and obesity
Semaglutide Cuts Insulin Needs By Half In Type 1 Diabetes
A post hoc analysis of an RCT found that semaglutide 1 mg/week significantly reduced total daily insulin dose by 22.6% over 26 weeks in adul…
Semaglutide reduces insulin needs quickly in type 1 diabetes patients, offering a new hope for better blood sugar control and weight managem…