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Infectious Disease
RCT
CRS3123 shows efficacy in phase 2 trial for Clostridioides difficile infection
Early trial shows CRS3123 matches vancomycin for treating C. diff infection
This phase 2 randomized trial compared CRS3123 with vancomycin in 43 adults with CDI.
A small Phase 2 trial found CRS3123 worked as well as vancomycin for curing C. diff infection in adults with their first episode or recurren…
May 1, 2026
Infectious Disease
Review of Fluoroquinolone Restriction Implementation Modifications for C. difficile Prevention
Hospital plans to stop risky drugs often changed during real-world rollout
This review analyzes modifications to fluoroquinolone restriction implementation strategies from the FIRST trial across four diverse hospita…
Plans to limit risky fluoroquinolones often changed during rollout. Rural hospitals needed more tweaks than academic centers.
medRxiv
Apr 30, 2026