Combined low-level laser and ultrasound therapy showed possible efficacy and safety for growing pains in children over 30 days
New therapy may ease growing pains without using medicine
This pilot randomized controlled trial evaluated combined low-level laser and ultrasound therapy versus placebo in children aged four to twe…
A new treatment using light and sound waves could help children stop hurting without taking pills
UK trial reports 4-year event-free survival of 63% and overall survival of 68% in relapsed Wilms tumour patients
High-dose chemo plus stem cell rescue offers hope for relapsed Wilms tumour
This clinical trial report evaluates outcomes for 78 children with relapsed or refractory Wilms tumour treated in the United Kingdom.
A UK trial found that a risk-stratified protocol with high-dose melphalan and stem cell rescue helped some children with relapsed Wilms tumo…
Six H5N1 vaccine formulations showed immunogenicity and acceptable safety in 420 healthy children aged 6 months to 9 years
Higher adjuvant content boosts immunity in children without added safety risks
This phase 2, observer-blind, multicenter study evaluated six formulations of MF59-adjuvanted H5N1 vaccine in 420 healthy infants and childr…
A Phase 2 trial in healthy children found that higher adjuvant content improved immune responses to an H5N1 vaccine without increasing side …
Valganciclovir dosing in congenital cytomegalovirus infection shows extensive drug accumulation in dried blood spots
New blood test tracks cCMV drug levels in infants
This randomized, placebo-controlled clinical trial (ValEAR) or open-label PK study evaluated infants with congenital cytomegalovirus infecti…
A new blood spot test helps doctors track cCMV medicine levels in babies to prevent dangerous side effects during treatment.
High-dose rifampicin pharmacokinetics differ across sites in tuberculosis infection randomized trial
High-dose rifampicin shows different drug levels in adults across three countries
This randomized controlled trial evaluated adults and adolescents aged ≥ 10 years with tuberculosis infection.
Drug levels of high-dose rifampicin varied by country, with lower bioavailability seen in Canada and Vietnam compared to Indonesia in this t…
Vitamin A Supplementation at Birth Alters Vaccine Immune Responses Without Improving Antibody Levels in Infants
Vitamin A given at birth changes how babies respond to vaccines
This randomized, placebo-controlled trial enrolled 306 infants in Dhaka, Bangladesh receiving 50,000 IU Vitamin A within 48 hours of birth c…
A single vitamin A dose at birth may strengthen some vaccine responses in infants, but results vary by sex and vaccine type.
Meta-analysis shows clear aligners produce less skeletal expansion than conventional appliances in growing patients
Clear Aligners Produce Less Skeletal Expansion Than Conventional Appliances
This systematic review and meta-analysis evaluated clear aligners versus conventional expansion appliances for maxillary transverse deficien…
A review of 15 studies finds clear aligners create less skeletal expansion than traditional devices for growing patients with maxillary tran…
Narrative review discusses telemedicine potential and barriers for new immigrant children in the US
Telemedicine could help bridge healthcare gaps for immigrant children
This narrative review examines the acceptance, accessibility, and feasibility of telemedicine for new immigrant children in the US aged birt…
New immigrant families face massive hurdles in healthcare, but virtual doctor visits might help overcome language and travel barriers.
Containment surgery and radiographic outcomes in children with Waldenström stage III LCPD
Surgery shows potential benefits for advanced Legg-Calvé-Perthes disease
This retrospective cohort study of 58 children with Waldenström stage III LCPD observed an association between containment surgery and femor…
A study of children with advanced Legg-Calvé-Perthes disease found a trend toward better hip development after containment surgery.
Disease progression and death in a 10 year old male with lower esophageal squamous cell carcinoma
Rare case: child dies 7 months after esophageal cancer diagnosis
This case report and retrospective literature analysis describes a 10 year old male with lower esophageal squamous cell carcinoma.
A 10-year-old with a rare esophageal cancer died 7 months after diagnosis, highlighting the urgent need for better treatments.
Azithromycin to doxycycline switching in children with Mycoplasma pneumoniae pneumonia resistance gene positivity
Testing for resistance genes may guide antibiotic choices
This retrospective cohort study of 150 children with Mycoplasma pneumoniae pneumonia evaluated resistance gene expression and antibiotic man…
New evidence suggests that checking for resistance genes in children with pneumonia could help doctors decide when to switch antibiotics.
Routine lab indicators help differentiate typical from incomplete Kawasaki disease and predict coronary lesions
Lab indicators may help identify Kawasaki disease risks
This retrospective study of 131 children with Kawasaki disease found that total protein was the only independent factor differentiating typi…
Routine blood markers could help doctors better identify Kawasaki disease types and predict potential heart complications in children.