Respiratory microbiome composition in children offers new ideas for precision treatment of respiratory diseases and asthma
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Key Takeaway
Consider the respiratory microbiome as a direction for future research on pediatric respiratory disease pathogenesis.
This narrative review focuses on the respiratory microbiome, including its composition, metabolites, and colonization status within pediatric populations. The scope covers children affected by respiratory infections, allergic airway inflammation, asthma, and other respiratory diseases. The authors discuss how these factors relate to the broader context of respiratory health in this age group.
The authors provide new ideas and directions for research on pathogenesis and clinical precision treatment based on the available information. No specific quantitative results, p-values, or confidence intervals were reported in this source. Safety data, including adverse events and tolerability, were not reported in this source.
The review does not establish causal links between microbiome changes and clinical outcomes. The findings are intended to guide future research rather than inform immediate clinical practice. Limitations regarding the lack of specific data are acknowledged through the absence of reported numerical outcomes.
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View Original Abstract ↓
Respiratory diseases are common and frequently occurring illnesses in children. In recent years, studies have confirmed that the respiratory microbiome is closely associated with the susceptibility and severity of respiratory diseases in children, and its microbial composition and metabolites are involved in the occurrence and development of respiratory infections, allergic airway inflammation, asthma and other disorders. Based on the cutting-edge research findings of the past 2–3 years, this review systematically summarizes the composition and sources of the respiratory microbiome in children, the characteristics of its colonization and dysbiosis, the interaction mechanisms with the host immune system, as well as the correlation rules with common respiratory diseases. It also focuses on elaborating novel therapeutic strategies such as probiotic therapy, phage therapy, and antimicrobial peptide (AMP) therapy, aiming to provide new ideas and directions for the research on the pathogenesis and clinical precision treatment of childhood respiratory diseases.
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