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Patient Mode — summaries use plain language, avoiding clinical jargon.
Diabetes & Endocrinology
Guideline
Guideline on severe pediatric obesity with MC4R variant and puberty management
Two siblings with severe obesity and early puberty found to have genetic changes affecting their growth and health over fourteen years
This guideline, based on a case report of two Chinese siblings with a heterozygous MC4R variant, synthesizes long-term management of monogen…
Two Chinese brothers with severe obesity and early puberty received special treatments for fourteen years. Their puberty slowed down, blood …
Frontiers
May 2, 2026
Diabetes & Endocrinology
Meta-analysis
Network meta-analysis finds GnRHa trigger reduces OHSS risk versus hCG in predicted high responders undergoing IVF
Study compares four IVF trigger methods for women at high risk of over-response
A network meta-analysis of 7 RCTs involving 632 predicted high responders undergoing IVF with GnRH antagonist protocols compared four final …
For women at high risk of painful IVF complications, a specific hormone trigger shot significantly lowers that risk without reducing egg cou…
Frontiers
Apr 8, 2026