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Home › Conditions › Dengue

Dengue

Part of Flavivirus Infections

14 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Dengue

35 trials tracked for Dengue: 6 in phase 3 or 4 and 3 with published results. The most-cited published study has 1074 citations.

35Trials tracked
6Phase 3 & 4
0Recruiting
3With published results
Phase distribution
Phase 3 6 Phase 2 19 Phase 1 4 Other / NA 6
  1. Phase 3 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children and Adolescents Aged 9 to 16 Years in Latin America Completed · 1,074 cited
  2. Phase 3 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) Administered With a Yellow Fever Vaccine in Adults Completed · 27 cited
  3. Phase 3 Immunogenicity and Safety of Tetravalent Dengue Vaccine (TDV) in Adolescents in Non-Endemic Area(s) Completed · 21 cited
  4. Phase 3 Study of a Booster Injection of Pentaxim™ Vaccine Administered With Dengue Vaccine in Healthy Toddlers Completed
  5. Phase 3 Study of Yellow Fever Vaccine Administered With Tetravalent Dengue Vaccine in Healthy Toddlers Completed
  6. Phase 3 Study of a Novel Tetravalent Dengue Vaccine in Healthy Children Aged 2 to 14 Years in Asia Completed
Show 29 more trials
  1. Phase 2 A Trial of a Walter Reed Army Institute of Research (WRAIR) Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy US Adults Completed
  2. Phase 2 Study of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Subjects in Singapore Completed
  3. Phase 2 Immunogenicity and Safety of Sanofi Pasteur's CYD Dengue Vaccine in Healthy Children and Adolescents in Latin America Completed
  4. Phase 2 Study of CYD Dengue Vaccine in Healthy Children and Adolescents in South America Completed
  5. Phase 2 A Phase I/II Trial of Tetravalent Live Attenuated Dengue Vaccine in Flavivirus Antibody Naive Infants Completed
  6. Phase 2 Immunogenicity and Safety of Three Formulations of Dengue Vaccines in Healthy Adults Aged 18 to 45 Years in the US Completed
  7. Phase 2 A Phase I/II Trial of a Tetravalent Live Attenuated DEN Vaccine in Flavivirus Antibody Naive Children Completed
  8. Phase 2 Efficacy and Safety of Dengue Vaccine in Healthy Children Completed
  9. Phase 2 Safety and Immunogenicity of the Dengue Virus Vaccine TV005 (TetraVax-DV TV005) in Healthy Adults, Adolescents, and Children in Dhaka, Bangladesh Completed
  10. Phase 2 Study of a Tetravalent Dengue Vaccine in Healthy Adult Subjects Aged 18 to 45 Years in India Completed
  11. Phase 2 An Evaluation of Repeated Oral Doses of JNJ-64281802 Against DENV-3 Challenge Completed
  12. Phase 2 Safety and Immunogenicity of Three V181 Dengue Vaccine Potencies in Adults (V181-003) Completed
  13. Phase 2 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Subjects Completed
  14. Phase 2 Clinical Bridging Study Between V181 (Dengue Quadrivalent Vaccine rDENVΔ30 [Live, Attenuated]) to Butantan Dengue Vaccine (Butantan - DV) in Healthy Adults 18 to 50 Years of Age in Brazil (V181 - 002) Completed
  15. Phase 2 A Phase II Trial of a Live Attenuated Virus Tetravalent Dengue Vaccine in Healthy Adults in Thailand Completed
  16. Phase 2 Safety and Immunogenicity of Various Formulations of Live Attenuated Tetravalent Dengue Vaccine in Healthy US Adults Completed
  17. Phase 2 Study of ChimeriVax™ Tetravalent Dengue Vaccine in Healthy Peruvian Children Aged 2 to 11 Years Completed
  18. Phase 2 Immune Response to Different Schedules of a Tetravalent Dengue Vaccine Given With or Without Yellow Fever Vaccine Completed
  19. Phase 2 Immunologic Mechanisms of Immune Interference and/or Cross-Neutralizing Immunity After CYD Tetravalent Dengue Vaccine Completed
  20. Phase 1 Immunogenicity of an Intradermal Qdenga Vaccine Among Healthy Volunteers Completed
  21. Phase 1 ADVP005; Dengue CVD 12000 - Dengue-1-Virus Live Virus Human Challenge (DENV-1-LVHC) Completed
  22. Phase 1 Safety and Immunogenicity Study of a Dengue Virus DNA Vaccine Completed
  23. Phase 1 Dengue 4 Human Infection Model (Dengue CVD 11000; DHIM-4) Completed
  24. N/A Study to Evaluate the Incidence, Clinical Characteristics and Economic Burden of Dengue in Brazilian Children Completed
  25. N/A A Prospective, Open Label, Treatment Use Study of Patient Safety Following Transfusion of INTERCEPT Platelet Components Completed
  26. N/A Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases Completed
  27. N/A Long-Term Study of Hospitalized Dengue & Safety in Thai Children Included in a Tetravalent Dengue Vaccine Efficacy Study Completed
  28. N/A Defining Skin Immunity of a Bite of Key Insect Vectors in Humans Completed
  29. N/A A Cohort Study to Determine the Incidence of Dengue Fever and to Build Capacity for Dengue Vaccine Trials in Dengue-endemic Regions of South Asia Completed

Showing the 35 most-cited and recently-updated of 35 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Dengue vaccines lower viremia rates and hemorrhagic fever risk compared to placebo in a meta-analysis of 175434 participants
Emergency Medicine Meta-analysis
Dengue vaccines lower viremia rates and hemorrhagic fever risk compared to placebo in a meta-analysis of 175434 participants Dengue vaccines show lower rates of infection and severe fever compared to placebo
This meta-analysis evaluated dengue vaccines versus placebo across 175434 participants. The analysis found lower rates of viremia and hemorr…
A large analysis of dengue vaccines shows they lower the risk of infection and severe fever, with antibody production also increasing.
Jun 1, 2026
One in six blood donors in Cameroon carries Plasmodium infection, meta-analysis finds
Infectious Disease Meta-analysis
One in six blood donors in Cameroon carries Plasmodium infection, meta-analysis finds 1 in 6 blood donors in Cameroon carries malaria parasite
A systematic review and meta-analysis of 18 studies (~12,500 donations) found a 16.6% pooled prevalence of Plasmodium spp. in Cameroonian bl…
A review of 18 studies finds 16.6% of blood donations in Cameroon contain Plasmodium, the malaria parasite.
May 30, 2026
Qualitative review of digital surveillance challenges for dengue in western India
Primary Care & Family Medicine Sys. Review
Qualitative review of digital surveillance challenges for dengue in western India Digital tools face real hurdles in India's fight against dengue
This qualitative review examines digital surveillance systems for dengue in two high-burden districts of western India. Based on 57 semi-str…
Digital surveillance systems struggle with fragmented data and community resistance in western India, complicating dengue outbreak warnings.
Frontiers May 26, 2026
Environmental and social factors influence arbovirus proliferation in changing climate conditions
Infectious Disease Cohort
Environmental and social factors influence arbovirus proliferation in changing climate conditions Rising Temperatures Push Dangerous Viruses Into New Communities
This review examines how environmental and social factors, including increasing temperatures and urbanization, affect the proliferation of a…
Warming weather pushes dangerous insect-borne viruses into new areas, making early warning systems and vaccines more critical than ever for …
Frontiers Apr 28, 2026
Observational study evaluates clinical prediction models for dengue, chikungunya, and Oropouche fever in Brazil
Infectious Disease
Observational study evaluates clinical prediction models for dengue, chikungunya, and Oropouche fever in Brazil New Tool Helps Doctors Tell Dengue, Chikungunya, and Oropouche Fever Apart
This observational study analyzed surveillance data from Espirito Santo state, Brazil, involving 465,280 observations to assess clinical pre…
A new online tool can tell apart dengue, chikungunya, and Oropouche fever using simple symptoms, helping doctors make faster, more accurate …
medRxiv Apr 26, 2026
Dengue outbreak triggers local public health emergency in Puerto Rico
Infectious Disease
Dengue outbreak triggers local public health emergency in Puerto Rico Why did Puerto Rico declare a public health emergency over dengue?
A report from Puerto Rico indicates a dengue outbreak has triggered a local public health emergency.
Puerto Rico declared a public health emergency after dengue cases surged across the island in 2024, prompting urgent government action to co…
CDC Apr 5, 2026
Field report describes increase in dengue cases in Peru during 2023
Infectious Disease
Field report describes increase in dengue cases in Peru during 2023 Field report describes increase in dengue cases in Peru during 2023
A descriptive field report from Peru documents an increase in dengue cases during 2023.
Peru health officials report increased dengue cases in 2023, prompting a closer look at mosquito-borne risks in the region.
CDC Apr 5, 2026
Dengue virus identified in Maricopa County, Arizona, according to field report
Infectious Disease
Dengue virus identified in Maricopa County, Arizona, according to field report Dengue virus identified in Maricopa County, Arizona, according to field report
A field report from Maricopa County, Arizona, describes the identification of dengue virus.
Dengue virus identified in Maricopa County, Arizona, prompting health officials to monitor mosquito-borne illness risks and remind residents…
CDC Apr 5, 2026
Surveillance summary describes epidemiologic trends of dengue in U.S. Territories
Infectious Disease
Surveillance summary describes epidemiologic trends of dengue in U.S. Territories Health officials track dengue cases in U.S. territories for patterns
A surveillance summary reports on epidemiologic trends of dengue cases in U.S.
CDC data shows dengue cases in U.S. territories like Puerto Rico and the Virgin Islands from 2010 to 2020, helping officials track the mosqu…
CDC Apr 5, 2026
Travel-associated dengue cases increased in the United States in 2019
Infectious Disease
Travel-associated dengue cases increased in the United States in 2019 Travel-related dengue cases in the U.S. increased in 2019, report shows
An observational report of travel-associated dengue cases in the United States from 2010 to 2021 found an increase in cases in 2019 compared…
Travelers brought more dengue cases to the U.S. in 2019 than in the years before or after, according to a new report.
CDC Apr 5, 2026
Surveillance system monitors dengue trends in Puerto Rico
Infectious Disease
Surveillance system monitors dengue trends in Puerto Rico What's happening with dengue in Puerto Rico? A new report tracks the trends
A surveillance summary describes a system used to monitor dengue trends in Puerto Rico.
A new report explains how Puerto Rico tracks dengue fever trends to spot outbreaks early and understand how the disease is spreading.
CDC Apr 4, 2026
Field report examines dengue virus infection prevalence in U.S. Virgin Islands youth
Pediatrics
Field report examines dengue virus infection prevalence in U.S. Virgin Islands youth How many kids in the U.S. Virgin Islands have had dengue?
A field report from the U.S. Virgin Islands assessed the prevalence of previous dengue virus infection in children and adolescents.
Health officials in the U.S. Virgin Islands are checking how common past dengue infections are among children and adolescents.
CDC Apr 4, 2026

Questions about Dengue

Can T cell epitope vaccines help control dengue virus infection?

T cell epitope vaccines show promise for controlling dengue by boosting cellular immunity and potentially reducing the risk of severe disease caused by antibody-dependent enhancement.

Full answer →
Why did travel-associated Dengue cases increase in the United States in 2019?

Travel-associated dengue cases in the U.S. surged in 2019 due to high global dengue activity and increased travel to endemic areas, with 1,474 cases reported — 168% above the annual average for other years.

Full answer →
What are the current epidemiologic trends of Dengue in U.S. Territories?

Dengue cases in U.S. Territories have risen significantly, with Puerto Rico declaring a local public health emergency in 2024 due to a surge in infections.

Full answer →
Why did Dengue cases increase in Peru during the year 2023?

Dengue cases rose in Peru in 2023 due to a combination of climate-driven environmental changes and the circulation of specific virus serotypes that increase severe disease risk.

Full answer →
Can clinical prediction models help identify Dengue cases in Brazil?

Yes, clinical prediction models using symptoms like leukopenia and vomiting can help identify dengue cases in Brazil, with good accuracy in a recent study.

Full answer →
See all 5 questions about Dengue →

All Dengue Articles