Narrative review of animal models in neuromyelitis optica spectrum disorder pathogenesis
Animal Models Are Unlocking New Treatments for Rare Brain Disease
This narrative review examines animal models used to study neuromyelitis optica spectrum disorder pathogenesis.
Better animal models are helping scientists understand how NMOSD damages the brain, offering hope for new treatments for patients with few o…
Phase 1b trial of intravenous B001 shows favorable safety in aquaporin-4-positive NMOSD patients
A New MS-Like Disease Drug Passes Its First Human Safety Test
This Phase 1b randomized, double-blind, placebo-controlled trial evaluated intravenous B001 in 22 patients with aquaporin-4 immunoglobulin G…
A new drug for a rare nerve disease that can cause blindness and paralysis passed its first human safety test with no severe side effects se…
Narrative review explores multimodal approaches for autoimmune diseases including rheumatoid arthritis and Crohn's
Scarring From the Inside: How Your Immune System Can Turn Against Your Own Organs
This narrative review examines the integration of immune modulation, epigenetic reprogramming, and mechanobiological interventions for autoi…
Your immune system can cause permanent scarring inside organs like lungs and joints, driving autoimmune diseases such as rheumatoid arthriti…
Oral cladribine reshapes CSF immune cell composition in relapsing multiple sclerosis
Cladribine therapy changes immune cells in fluid from the brain in a small MS study
This single-site phase IV clinical trial used single-cell sequencing on CSF and blood from 13 individuals with relapsing MS before and after…
Cladribine therapy reshapes immune cells in the brain's fluid by reducing harmful memory B cells while boosting protective Treg cells in mul…
Protocol for pilot RCT of neuromodulation-augmented balance training in ambulatory people with multiple sclerosis
New Balance Trick Helps MS Walkers Move Better
This published protocol describes a pilot randomized trial evaluating the feasibility, acceptability, safety, and preliminary clinical effic…
This new approach combines simple exercises with gentle electrical signals to help people with multiple sclerosis walk more confidently.
MRI outcomes show weak association with disability in primary progressive multiple sclerosis patients
MRI results show weak connection to disability changes in progressive multiple sclerosis
This Phase 3 trial secondary analysis evaluated 943 patients with primary progressive multiple sclerosis treated with glatiramer acetate ove…
MRI scans show weak links to disability changes in progressive multiple sclerosis, challenging their use as reliable trial endpoints for thi…
6-week multimodal exercise training feasible for frail people with multiple sclerosis in pilot RCT
Exercise Helps Frail MS Patients Feel Better
This pilot randomized controlled trial in 16 frail people with multiple sclerosis tested a 6-week multimodal exercise program versus waitlis…
A new exercise program combining virtual reality and resistance training helps frail people with multiple sclerosis feel better and move mor…
Meta-analysis finds respiratory muscle training improves some lung function measures in multiple sclerosis
Breathing Easier: New Hope for MS Patients
This systematic review and meta-analysis of 249 patients with multiple sclerosis synthesizes evidence on respiratory muscle training.
Breathing exercises strengthen chest muscles and improve airflow for people with Multiple Sclerosis who struggle to take a full breath.
Systematic Review Examines T-Cell Mechanisms and Therapies in Multiple Sclerosis
New Review Looks At Multiple Sclerosis Treatments And Immune System Mechanisms
This systematic review addresses multiple sclerosis, focusing on T-cell-mediated immunodysregulation mechanisms, disease-modifying therapies…
Multiple sclerosis, a leading cause of disability in young people, involves T-cell immune responses that drive inflammation and are targeted…
Real-world cohort examines Alemtuzumab effects on bowel/bladder function and latent progressive trajectories in MS patients
Did you know MS patients hide worsening symptoms that doctors might miss for years?
This real-world cohort study involving 1,025 MS patients utilized a trajectory-based statistical approach to analyze disease progression.
Doctors might miss worsening MS symptoms for years because patients hide them, but a new method found over 11,000 hidden patterns in real-wo…
EBV DNA positivity links to MS risk genes in a cross-ancestry study of 617,186 participants
A Common Virus May Hold the Key to MS — Here's Why
This cross-ancestry genome-wide association study analyzed 617,186 individuals to investigate the relationship between Epstein-Barr virus (E…
A virus almost everyone carries may quietly flip immune switches that set off multiple sclerosis by altering how B cells signal to T cells.
REDDI pipeline improves balanced accuracy for classifying MCI, MS, Parkinson's, and ALS using MEG data
Can a new computer tool help doctors spot brain diseases faster and more accurately?
This study developed a machine learning framework called REDDI that utilizes MEG resting-state data and Riemannian geometry for classifying…
A new computer tool helps doctors distinguish between hard-to-tell-apart brain diseases like Parkinson's and ALS with 13% better accuracy.