Parkinson's disease affects many people, but doctors often struggle to tell the different forms apart. A new analysis looked at a specific test called the alpha-synuclein seed amplification assay. This test looks for a protein that builds up in the brain. Researchers checked if this test could spot Parkinson's caused by a specific gene change known as LRRK2. They also looked at people with the common form of the disease and healthy people for comparison.
The results were clear for those with the gene variant. The test found the protein in 80 percent of patients with LRRK2-related Parkinson's. It also found the protein in just one person who had the gene change but did not have the disease. This difference helps doctors separate the two groups. The test performed very well overall, with a score of 0.97 for accuracy.
The study also found a link between the test results and a genetic score related to mitochondria. Higher genetic scores for mitochondrial issues were connected to more protein found in the test. This connection suggests that mitochondrial health plays a role in this specific type of Parkinson's. The research included data from Norway and a large international group of patients. While the findings are promising, the study notes that these results show an association rather than proving a direct cause.